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Oxytocin

Oxytocin is also called Pitocin, is a kind of uterine contraction medicine, can be extracted from animal posterior pituitary or chemical synthesis, chemical synthesis including on vasopressin, no booster effect, selective excitate uterine smooth muscle, strengthen its contracting, uterus is most sensitive to oxytocin (estrogen secretion increase) when parturient , immature uterus have no reactivity to this product, pregnancy early or middle uterine have low reactivity to oxytocin, late pregnancy is gradually increased, and before the antepartum, the reactivity is the highest.
Oxytocin Suppliers list
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Products Intro: Product Name:Oxytocin
CAS:50-56-6
Purity:99% Package:550/G
Company Name: Shenzhen JYMed Technology Co., Ltd.  Gold
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Products Intro:Product Name:oxytocin
CAS:50-56-6
Purity:98% Package:1.00RMB/1G
Company Name: Hangzhou Peptide Biochem Co.,Ltd  Gold
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Products Intro:Product Name:Oxytocin Acetate
CAS:50-56-6
Purity:98.5% Package:1g,10g,25g,100g Remarks:USP,EP
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Products Intro:Product Name:Oxytocin
CAS:50-56-6
Purity:99% Package:25kg/drum
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Products Intro:Product Name:Oxytocin Acetate
CAS:50-56-6
Purity:98% HPLC Package:5Mg;10Mg;1g
Oxytocin Basic information
Indications and Usage Mechanisms of Action Pharmacokinetics Adverse reactions Contradictions Warnings and Precautions
Product Name:Oxytocin
Synonyms:+CYS-TYR-ILE-GLN-ASN-+CYS-+PRO-LEU-GLY-NH2;CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2;CYIQNCPLG-NH2;CYIQNCPLG-NH2 (DISULFIDE BRIDGE: 1-6);H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2;H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, CYS1,6, CYCLIC;H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 (DISULFIDE BRIDGE: 1-6);A-HYPOPHAMINE
CAS:50-56-6
MF:C43H66N12O12S2
MW:1007.19
EINECS:200-048-4
Product Categories:Amino Acid Derivatives;Organics;Amino Acids 13C, 2H, 15N;Peptide;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Vasopressin and Oxytocin receptor;Peptide Receptors;hormones;peptides for birth-giving use;Veterinary drugs
Mol File:50-56-6.mol
Oxytocin Structure
Oxytocin Chemical Properties
Melting point 192-194°C
storage temp. 2-8°C
form lyophilized powder
color White
Water Solubility Soluble in water.
Merck 13,7049
CAS DataBase Reference50-56-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR 3249
WGK Germany 3
RTECS RS7534000
3-8-10-23
HazardClass 6.1(a)
PackingGroup II
Hazardous Substances Data50-56-6(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Oxytocin English
SigmaAldrich English
Oxytocin Usage And Synthesis
Indications and UsageOxytocin (OT) is a type of uterine contraction drug and can be derived from the animal posterior pituitary or chemically synthesized.
Oxytocin is a uterine contraction drug that is mostly used in late pregnancy induction and stagnant birth due to weak uterine contractions. Suitable for inducing labor and alleviating pain. Commonly used with ergot preparations to be used in inducing labor, expediting labor, and in uterine bleeding due to weak uterine contractions following birth or still birth. Nose drops can be used to promote lactation.
Mechanisms of ActionOxytocin does not contain vasopressin and has no pressure-boosting effects. It can be absorbed through oral mucosa, selectively excite smooth uterine muscle, and intensify its contractions. The uterus is most sensitive to oxytocin when in labor (due to increased estrogen secretion), and an immature uterus will not respond to this drug. During early or mid-term pregnancy, the uterus has a relatively low reactivity to oxytocin, which gradually increases during late-stage pregnancy and peaks during labor. Small doses can strengthen the rhythmic contractions of smooth uterine muscles, increase their contractibility, increase their contraction speed, ensure similar contraction characteristics to that of a natural birth, and maintain polarity and symmetry. Thus, it is used clinically to expedite and induce labor. Large doses cause tonic contractions in the uterine muscles, so it is used clinically to burst blood vessels between muscle fibers, prevent postpartum hemorrhage, and ensuring postpartum recovery. It can also promote lactation by causing the breast ducts to contract and expel milk from the breasts, but it cannot increase the lactation amount.
PharmacokineticsIneffective when taken orally, as it can be damaged by digestive fluids, although it can be absorbed through oral mucosa. 1-3 minutes of venous infusion 0.01 IU can induce physiological uterine contractions (Rhythmic, polar, symmetrical) with a short time span, as its half-life is only 2.5-3 minutes. Large doses cause tonic uterine contractions.
Adverse reactionsOxytocin derived from cow or pig’s pituitary occasionally causes allergic reactions, and infusing too quickly may lead to mild vasodilation and hypotension. Patients who suffer from abruptio placentae, heart disease, or enlarged uterus, are over 35 years old, have a history of cesarean section or uterine muscle tumor removal, or are experiencing a breech birth should use with caution. Using oxytocin while experiencing a sacral block may lead to severe hypertension and even cerebrovascular rupturing. Cannot be injected in the same solution with norepinephrine. Incompatible with hydrolyzed proteins.
ContradictionsDo not use during birth if there are obvious signs of an unsymmetrical head, incorrect fetal position, exposed umbilical cord, prolapse, complete placenta previa, narrow pelvis, or overly intense uterine contractions. Not to be used by patients with overly narrow pelvises, histories of uterine surgery (including C-sections), excessive pains, blocked birth canals, abruptio placentae, or pregnancy poisoning.
Warnings and PrecautionsDosage and infusion speed must be strictly monitored when used to expedite or induce labor to prevent tonic contractions, which can suffocate the fetus or rupture the uterus.
Chemical PropertiesWhite Solid
UsesOxytocin is the principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland.
DefinitionChEBI: A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is bel eved to influence social cognition and behaviour.
Tag:Oxytocin(50-56-6) Related Product Information
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