羰基氰化氯苯腙

羰基氰化氯苯腙

中文名称羰基氰化氯苯腙
中文同义词羰基氰酯-3-氯苯基腙,98%;羰基氰化间氯苯腙;羰基氰基3-氯苯腙/羰基氰化氯苯腙/CCCP;氰化羰基-3-氯苯腙;氰化羰基间氯苯腙;羰基氰酯-3-氯苯基腙;羰基氰化氯苯腙;羰基氰基3-氯苯腙
英文名称CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
英文同义词[(3-chlorophenyl)hydrazono]-propanedinitril;m-chlorophenylcarbonylcyanidehydrazone;mesoxalonitrile,(m-chlorophenyl)hydrazone;M-CL-CCP;MESOXALONITRILE (3-CHLOROPHENYL)HYDRAZONE;BUTTPARK 91\04-41;CARBONYL CYANIDE M-CHLOROPHENYL-HYDRAZONE;CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
CAS号555-60-2
分子式C9H5ClN4
分子量204.62
EINECS号209-103-7
相关类别抑制剂;化工原料;有机化工原料;标准品;Caspases/Apoptosis
Mol文件555-60-2.mol
结构式羰基氰化氯苯腙 结构式

羰基氰化氯苯腙 性质

熔点170-175 °C (dec.)
沸点333.84°C (rough estimate)
密度1.3807 (rough estimate)
折射率1.6110 (estimate)
储存条件-20°C
溶解度甲醇:10 mg/mL,澄清,深的黄色
形态粉末
酸度系数(pKa)6.00±0.10(Predicted)
颜色黄色至橙色粘性至蜡状
水溶解性Insoluble in water. Soluble in DMSO (5 mg/ml), ethanol (1 mg/ml) and methanol (10 mg/ml).
BRN1842102
暴露限值NIOSH: IDLH 25 mg/m3
InChIKeyUGTJLJZQQFGTJD-UHFFFAOYSA-N
CAS 数据库555-60-2(CAS DataBase Reference)
EPA化学物质信息Propanedinitrile, [(3-chlorophenyl)hydrazono]- (555-60-2)

羰基氰化氯苯腙 用途与合成方法

CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone)是一种氧化磷酸化抑制剂,是线粒体质子载体解偶联剂,可增加线粒体膜对质子的通透性,从而破坏线粒体膜电位。

STING
IFN-β

CCCP inhibits IFN-β production induced by various types of the STING pathway activators. CCCP suppresses the phosphorylation of STING, TBK1, and IRF3 via disrupting the association of STING and TBK1. CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region. CCCP impairs the interaction between STING and TBK1 and concomitantly triggers mitochondria fission. Importantly, the knockout of the crucial mitochondria fission regulator Drp1 restored the STING activity, indicating that CCCP down-modulates the STING pathway through DRP1-mediated mitochondria fragmentation. The protonophore CCCP that disrupts membrane potential suppresses the DMXAA-triggered STING signaling pathway. CCCP drastically suppresses the production of IFN-β in DMXAA-treated RAW264.7 cells and MEFs.

The same dosage of 3 mg/kg.bw each of CCCP and PPEF is used. In both the cases 1 log reduction is observed in the bacterial load. However, when 3 mg/kg.bw of PPEF is used in combination with 3 mg/kg.bw of CCCP, 6 log 10 reduction is observed in the bacterial count. The developed model validates the enhanced antibacterial activity of combination therapy. 99m Tc-MIBI signals in the hearts of SD rats administered CCCP (4 mg/kg intraperitoneally) or vehicle is also measured. 99m Tc-MIBI signals decrease in rat hearts administered CCCP, and the ATP content, as measured by 31 P magnetic resonance spectroscopy, decreased simultaneously. To investigate whether CCCP decreased the 99m Tc-MIBI signals in rats, we analyzed the radioisotope activity of excised heart tissue from rats administered CCCP. At 180 min after 99m Tc-MIBI injection, the 99m Tc-MIBI signals from the hearts in the CCCP group are significantly lower than those in the vehicle group.

安全信息

危险品标志T
危险类别码23/24/25-36/37/38
安全说明26-36/37-45
危险品运输编号UN 2811 6.1/PG 3
WGK Germany3
RTECS号FG5600000
TSCAYes
危险等级6.1
包装类别III
海关编码29280090

MSDS信息

提供商 语言
英文
英文
中文
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-100941CCCP10 mg250元
2024/01/25HY-100941羰基氰化氯苯腙
CCCP
555-60-250mg500元

羰基氰化氯苯腙 上下游产品信息

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米酵菌酸铵盐标准品 碳酰氰-4-三氟甲氧基苯腙 3-氯苯肼盐酸盐 甲基肼 盐酸肼 丙二腈 间氯苯胺 盐酸苯胺 丙腈 水合肼 羰基氰化氯苯腙 苯肼 盐酸苯肼 丙酮苯腙
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