萘啶酮酸钠
| 中文名称 | 萘啶酮酸钠 |
|---|---|
| 中文同义词 | 萘啶酮酸钠盐;萘啶酮酸钠(萘啶酸钠盐、1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸钠盐、萘啶酮酸钠盐);1-乙基-1,4-二氢-7-甲基-4-氧代-1,8-萘啶-3-羧酸钠盐;萘啶酮酸钠;萘啶酸钠盐;1-乙基-7-甲基-4-氧代-1,4-二氢-1,8-二氮杂萘-3-羧酸钠盐 |
| 英文名称 | Nalidixic acid sodium salt |
| 英文同义词 | NALIDIXIC ACID SODIUM SALT;1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylicacidsodium;8-naphthyridine-3-carboxylicacid,1-ethyl-1,4-dihydro-7-methyl-4-oxo-sodiu;1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID SODIUM SALT;nalidixatesodium;sodiumnalidixate;sodiumnilixalate;sodium 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate |
| CAS号 | 3374-05-8 |
| 分子式 | C12H13N2NaO3 |
| 分子量 | 256.24 |
| EINECS号 | 222-159-7 |
| 相关类别 | 合成;小分子抑制剂;中间体;有机化工原料;CEBESINE;antibiotic |
| Mol文件 | 3374-05-8.mol |
| 结构式 |  |
萘啶酮酸钠 性质
| 熔点 | >280℃ |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | H2O：50 mg/mL，清澈，淡黄色 |
| 形态 | 粉末 |
| 水溶解性 | Soluble at 50mg/ml in water |
| BRN | 3580062 |
| CAS 数据库 | 3374-05-8(CAS DataBase Reference) |
|
Topoisomerase
|
Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli , Pasteurella spp. , Klebsiella pneuiiioniae , Aerobacter aeroyenes , Proteus spp. , Salmonella spp. , Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively.
The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli , A. aerobacter , Proteus mirabilis , Shigella fkxneri , the ED 50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively. The acute toxicity (LD 50 ) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 42/43 |
| 安全说明 | 22-36/37-45 |
| WGK Germany | - |
| RTECS号 | QN2885500 |
| F | 8-10 |
| 海关编码 | 29339900 |
| 提供商 | 语言 |
|---|---|
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英文
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