CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])

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Products Intro: Product Name:Cyclo-Somatostatin
CAS:84211-54-1
Purity:>98% HPLC Package:5mg; 25mg; 100mg; 1g; 5g; 25g;100g Remarks:A0011
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Products Intro: Product Name:CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])
CAS:84211-54-1
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Products Intro: Product Name:Cyclo-Somatostatin
CAS:84211-54-1
Purity:98% Min. Package:5KG;1KG
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Products Intro: Product Name:Cyclosomatostatin
CAS:84211-54-1
Purity:NLT 98% Remarks:MC573903

CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) manufacturers

CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Basic information
Product Name:CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])
Synonyms:CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]);CYCLO-SOMATOSTATIN;C[AMINOHEPTANOYL-PHE-DTRP-LYS-THR(BZL)];somatostatin, cyclo-(7-Ahep-Phe-Trp-Lys-Bzl-Thr)-;Somatostatin Antagonist;cyclo-(7-ahep-phe-trp-lys-bzl-thr)-somatostati;Cyclo-Somatostatin acetate salt Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl)) acetate salt;Cyclo[7-aminoheptanoyl-L-phenylalanyl-D-tryptophyl-L-lysyl-O-(phenylmethyl)-L-threonyl]
CAS:84211-54-1
MF:C44H57N7O6
MW:779.97
EINECS:
Product Categories:
Mol File:84211-54-1.mol
CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Structure
CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Chemical Properties
Boiling point 1118.4±65.0 °C(Predicted)
density 1.147±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility H2O: 1 mg/mL, clear, colorless
form powder
pka12.83±0.70(Predicted)
color white
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Usage And Synthesis
UsesCyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) has been used as a somatostatin antagonist to study its effects on sleep in rats to infer the role of endogenous somatostatin in the physiologic modulation of REM sleep (REMS) , as an somatostatin (SST) antagonist to study its effects on elemental-induced intestinal atrophy in rats , as an SST receptor antagonist to eliminate the effect of somatostatin on catecholamine .
Biological Activitycyclosomatostatin is a non-selective somatostatin receptor antagonist.somatostatin is a regulatory hormone or tissue factor playing an inhibitory role in the normal regulation of several organ systems including hypothalamus and pituitary gland, central nervous system, gastrointestinal tract as well as pancreas.
Biochem/physiol ActionsCyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) (cSSTA) is a cyclic somatostatin (SST) analog and is a somatostatin receptor antagonist. It is involved in blocking the effect of somatostatin, such as airway β-adrenergic function and regulation of acetylcholine release. cSSTA is also involved in blocking the effect of somatostatin of hormone release and?corticotropin-releasing factor-induced suppression of gastric emptying.
in vitroalthough cyclosomatostatin could fully block the effect of somatostatin, it only partially reversed the inhibitory effect of cortistatin, a new anti-inflammatory peptide. this observation was further supported by the fact that cyclosomatostatin reversed the antiinfl ammatory effect of somatostatin and octreotide in vitro completely, while only partially reversing the effect of cortistatin [1].
in vivothe effect of cortistatin was found to be dose dependent, with dose as low as 0.5 nmol (50 μg/kg) being partially protective. in contrast, cyclosomatostatin, somatostatin as well as octreotide were not protective [1].
storageStore at -20°C
references[1] gonzalez-rey e,chorny a,robledo g,delgado m. cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia. j exp med.2006 mar 20;203(3):563-71.
CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) Preparation Products And Raw materials
Tag:CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL])(84211-54-1) Related Product Information
DL-Threonine hydrate(2:1) Somatostatin TYR-(D-DAB4,ARG5,D-TRP8)-CYCLO-SOMATOSTATIN-14 (4-11) N,N'-DI-N-HEXYL ETHYLENEDIAMINE (R)-3-(BENZYLOXY)BUTANAMIDE CYCLO(7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR[BZL]) CYCLO(-7-AMINOHEPTANOYL-PHE-D-TRP-LYS-THR(BZL)) ACETATE SALT