6-氰基-7-硝基喹喔啉-2,3-二酮
| 中文名称 | 6-氰基-7-硝基喹喔啉-2,3-二酮 |
|---|---|
| 中文同义词 | 6-氰基-7-硝基喹喔啉-2,3-二酮;1,2,3,4-四氢-7-硝基-2,3-二氧代-6-喹喔啉甲腈;3-二氧代-6-喹喔啉甲腈;4-四氢-7-硝基-2;CNQX,AMPA /海藻酸盐拮抗剂 |
| 英文名称 | CNQX |
| 英文同义词 | 7-Nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile;6-CYANO-7-NITROQUINOXALINE-2,3 (1H,4H)-DIONE;CNQX;CNQX 2NA;CNQX DISODIUM;CNQX DISODIUM SALT;FG-9065;CNQX DISODIUM KAINATE/AMPA RECEPTOR |
| CAS号 | 115066-14-3 |
| 分子式 | C9H4N4O4 |
| 分子量 | 232.15 |
| EINECS号 | |
| 相关类别 | 合成;Heterocyclic Compounds;Neurochemicals;Glutamate receptor;Glutamate;Aromatics;Heterocycles |
| Mol文件 | 115066-14-3.mol |
| 结构式 |  |
6-氰基-7-硝基喹喔啉-2,3-二酮 性质
| 熔点 | 300 °C |
|---|---|
| 沸点 | 374.31°C (rough estimate) |
| 密度 | 1.5507 (rough estimate) |
| 折射率 | 1.6590 (estimate) |
| RTECS号 | VD1520000 |
| 储存条件 | protect from light |
| 溶解度 | 在水中的溶解度10 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.16±0.20(Predicted) |
| 颜色 | 橙色至红色 |
| 稳定性 | 在室温下密封存放 |
| CAS 数据库 | 115066-14-3(CAS DataBase Reference) |
IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)
CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.
| Animal Model: | Male Wistar rats weighing 180-200 g |
| Dosage: | 0.75, 1.5, and 3 mg/kg |
| Administration: | IP; 20 min before testing |
| Result: | Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval |
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