α-倒捻子素
| 中文名称 | α-倒捻子素 |
|---|---|
| 中文同义词 | 曼果斯廷;1,3,6-三羟基-7-甲氧基-2,8-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮;Α-倒捻子素(标准品);ALPHA-倒捻子素;楝子素;山竹果提取物倒捻子素10%-95%;Α-倒捻子素(曼果斯廷,楝子素);Α-倒捻子素、曼果斯廷 |
| 英文名称 | Mangostin |
| 英文同义词 | α-Mangostin (a-Mangostin、ALPHA-Mangostin);α-Mangostin, froM Garcinia Mangostana;1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-on;Alpha-Mangostin α-Mangostin;1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one;1,3,6-TRIHYDROXY-7-METHOXY-2,8-DI(3-METHYL-2-BUTENYL)XANTHONE;Mangosteen;mangostin |
| CAS号 | 6147-11-1 |
| 分子式 | C24H26O6 |
| 分子量 | 410.46 |
| EINECS号 | 683-120-1 |
| 相关类别 | 分析标准品;中药对照品;标准品;植物提取物;中草药成分;植提标准品;对照品;植物生化提取物;提取物;医药原料;标准植物提取物;标准产品;氧杂蒽酮;标准品 -中药标准品;分析试剂-化学分析;标准品，对照品;标准提取物;标准品-对照品;主营推荐产品;植物单体;比例提取物;微粉、复方、比例提取物;生物化工;高定高含量产品;Xanthones;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reagent;standard substance |
| Mol文件 | 6147-11-1.mol |
| 结构式 |  |
α-倒捻子素 性质
| 熔点 | 180-182°C |
|---|---|
| 沸点 | 640.1±55.0 °C(Predicted) |
| 密度 | 1.265±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于甲醇：1mg/mL，透明，淡黄色 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 7.22±0.20(Predicted) |
| 颜色 | 淡黄色至黄色 |
| 最大波长(λmax) | 346nm(MeOH)(lit.) |
| 稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 1 个月。 |
| InChI | InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3 |
| InChIKey | GNRIZKKCNOBBMO-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=C(O)C(OC)=C2C/C=C(/C)\C)OC2=C1C(O)=C(C/C=C(/C)\C)C(O)=C2 |
| CAS 数据库 | 6147-11-1(CAS DataBase Reference) |
IC50: 2.85 μM (IDH1-R132H)
alpha-Mangostin (α-Mangostin) exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. alpha-Mangostin (α-Mangostin) competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-Mangostin (α-Mangostin) exhibits the strongest core inhibitor structure. alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). alpha-Mangostin (α-Mangostin) significantly inhibits light-induced degeneration of photoreceptors and 200 μM H 2 O 2 -induced apoptosis of RPE cells. 200 μM H 2 O 2 -induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-Mangostin (α-Mangostin).
alpha-Mangostin (α-Mangostin) reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.
药理药效:具有抗氧化、抗炎、抗菌、抗癌等药理活性
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 25 |
| 安全说明 | 45 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 1 |
| RTECS号 | ZD6122420 |
| 海关编码 | 29329990 |
| 毒害物质数据 | 6147-11-1(Hazardous Substances Data) |