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Diacerein

Diacerein Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:13739-02-1
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Diacerein
CAS:13739-02-1
Purity:98% Package:2674/KG
Company Name: J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro:Product Name:Diacerein
CAS:13739-02-1
Purity:98% Package:1G,250MG
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel:+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
Email:sh@meryer.com
Products Intro:Product Name:Diacerein
CAS:13739-02-1
Purity:>98.0%(LC) Package:1g;5g Remarks:D4061
Company Name: INTATRADE GmbH  
Tel:+49 3493/605464
Email:sales@intatrade.de
Products Intro:Product Name:Diacerein (1,8-Diacetoxy-3-carboxyanthraquinone)
CAS:13739-02-1
Remarks:IS04977
Diacerein Basic information
Immunosuppressive drugs Uses
Product Name:Diacerein
Synonyms:1,8-DIACETOXY-3-CARBOXYANTHRAQUINONE;DIACEREIN;DIACERHEIN;DIACETYL RHEIN;1,8-diacetoxyanthraquinone-3-carboxylicacid;4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylicaci;4,5-diacetylrhein;4,5-Diacetoxy-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
CAS:13739-02-1
MF:C19H12O8
MW:368.29
EINECS:237-310-2
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Pyridines ,Halogenated Heterocycles;Miscellaneous Biochemicals;Aromatics Compounds;Aromatics;Heterocycles
Mol File:13739-02-1.mol
Diacerein Structure
Diacerein Chemical Properties
Melting point 217-2180C
storage temp. Refrigerator
Merck 14,2960
CAS DataBase Reference13739-02-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS CB8781000
HS Code 29146990
MSDS Information
ProviderLanguage
1,8-Diacetoxy-3-carboxyanthraquinone English
SigmaAldrich English
Diacerein Usage And Synthesis
Immunosuppressive drugsDiacerein is a novel interleukin (IL)-1 inhibitor , the chemical name is diacetyl rhein,it is a compound of anthraquinones, the product can induce cartilage generation, it has analgesic, antipyretic and anti-inflammatory effects, but also it can significantly improve joint function in patients with osteoarthritis, and delay duration, and reduce pain to improve the quality of life of patients, it has better security, it is mainly used in clinical treatment of osteoarthritis (OA) to exert an antibacterial effect.
Solubility: soluble in dimethyl sulfoxide, dimethyl acetamide; insoluble in water, methanol, chloroform.
Diacerein and its active metabolite rhubarb (rhein) can reduce the generation and activity of IL-1β by inhibiting IL-1 converting enzyme. Mechanisms include:
1, inhibit the IL-1 synthesis of synovial tissue.
2, inhibit the expression of IL-1 receptor in chondrocytes .
3, inhibition of IL-1 activity.
4, repress formation of metalloproteinases such as collagenase and matrix dissolved elements and peroxide.
5, promote the synthesis of collagen and glycosaminoglycan.
6, inhibit the leukocyte chemotaxis and lysosomal stability.
Diacerein does not change the cyclooxygenase activity of kidneys and platelets, and does not inhibit the synthesis of prostaglandin , so prostaglandin-dependent renal dysfunction patients can tolerate.
Oral 50mg, PPB is 99%, Tmax is 2.2 h, Cmax is 3.2 mg/L, AUC is 21.3 mg • h/L, T1/2β is 4.3 h. Tmax and AUC values can be increased if it is administrated with food .
Adverse reactions: 50% of patients suffer diarrhea, abdominal pain and loose stools.
The above information is edited by the chemicalbook of Tian Ye.
UsesIt is widely used in new liquid crystal polymer, engineering plastics and high-strength fibers with high performance.
This product is an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis.
It is a natural antioxidant, it has anti-aging, enhance immunity, removing sub-health state, physical recovery, increasing energy and body immunity effects.
Chemical PropertiesYellow Crystalline Solid
UsesA diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic
Usesantiinflammatory
UsesA diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.
UsesTreatment of Osteoarthritis (Prevent cartilage destruction)
UsesDiacerein is a diacetyl precursor of rhein, an anthraquinone found in plants. Rhein, at 10 μM, inhibits IL-1β signaling, suppressing signaling through NF-κB and AP-1, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. Diacerein, presumably after conversion to rhein, down-regulates the expression of the IL-1β receptor on articular chondrocytes, enhances the expression of TGF-β, and increases collagen and aggrecan. It does not alter COX activity. It is mildly effective in ameliorating osteoarthritis.
Diacerein Preparation Products And Raw materials
Tag:Diacerein(13739-02-1) Related Product Information
Meloxicam Diacerein ANTHRAQUINONE-2-CARBOXYLIC ACID 4-FORMYL-3-HYDROXYBENZOIC ACID 3-METHOXY-3'-METHYLBENZOPHENONE 3-ACETOXYBENZOIC ACID 2-ACETOXYBENZOPHENONE 3-ACETOXY-3'-METHOXYBENZOPHENONE 3'-Acetoxyacetophenone 3-ACETOXYBENZOPHENONE Chrysophanic acid 3-METHOXY-5-METHYLBENZALDEHYDE 4-ETHYL-3-HYDROXYBENZOIC ACID 3-ACETOXY-3'-METHYLBENZOPHENONE 1,8-dimethoxyanthraquinone Aloe emodin 3-ACETOXY-2'-METHYLBENZOPHENONE 2,4-DIMETHYL-2'-METHOXYBENZOPHENONE