| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:ChroMonar Hydrochloride
CAS:655-35-6
Package:250Mg,25Mg
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| Company Name: |
Chemsky (shanghai) International Co.,Ltd
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:ChroMonar Hydrochloride;2-[[3-[2-(DiethylaMino)ethyl]-4-Methyl-2-oxo-2H-1-benzopyran-7-yl]oxy]acetic Acid Ethyl Ester Hydrochloride; 3-(2-DiethylaMinoethyl)-4-Methyl-7-carbethoxyMethoxy
-2-oxo-1,2-chroMene Hydrochloride; CarbochroMen Hydrochloride; Carboc
CAS:655-35-6
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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CARBOCROMENE HYDROCHLORIDE manufacturers
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| | CARBOCROMENE HYDROCHLORIDE Basic information |
| | CARBOCROMENE HYDROCHLORIDE Chemical Properties |
| Melting point | 159-160° | | solubility | Chloroform (Slightly), Methanol (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White |
| Toxicity | LD50 in mice (g/kg): 6.3 orally; 0.528 i.p.; 0.0355 i.v. (Nitz, Potzch) |
| | CARBOCROMENE HYDROCHLORIDE Usage And Synthesis |
| Originator | Intensain,Hoechst,Switz,1963 | | Uses | Vasodilator (coronary). | | Definition | ChEBI: Carbocromen hydrochloride is a member of coumarins. | | Manufacturing Process | 18.7 g of 3β-diethylaminoethyl-4-methyl-7-hydroxy-coumarin chlorhydrate are
dissolved in 200 cc methyl ethyl ketone and 18 g anhydrous potassium
carbonate are added. The mixture is stirred for 1 hour at 70°C and then 12 g
bromoacetic acid ethyl ester are allowed to drop in. The reaction mixture is
stirred under reflux for 9 hours and then it is filtered off with suction in the
heat. The filtrate is concentrated in the vacuum to dryness and the resultant
residue is dissolved in ether. The etheric solution is washed with diluted
caustic soda solution for several times and, subsequently, dried with Glauber's
salt. By introduction of hydrochloric acid gas into the etheric solution the
reaction product is precipitated in the form of chlorhydrate. Yield: 15 g of 3β-
diethylaminoethyl-4-methylcoumarin-7-ethyl oxyacetate chlorhydrate having a
melting point of 154° to 156°C (= 63% of the theory).
The starting material is produced by reacting resorcinol with 2-(2-
diethylaminoethyl)acetic acid ethyl ester. | | Therapeutic Function | Coronary vasodilator |
| | CARBOCROMENE HYDROCHLORIDE Preparation Products And Raw materials |
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