clofedanol manufacturers
- Clofedanol
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- $0.01 / 1KG
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2020-04-25
- CAS:791-35-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50 tons
- clofedanol
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- $8.80 / 1KG
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2019-07-14
- CAS: 791-35-5
- Min. Order: 1KG
- Purity: 97%-99%
- Supply Ability: 100kg
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| | clofedanol Basic information |
| Product Name: | clofedanol | | Synonyms: | 1-(2-chlorophenyl)-3-dimethylamino-1-phenylpropan-1-ol;clofedanol;clofedano;CHLOPHENDIANOL;1-o-Chlorophenyl-1-phenyl-3-dimethylamino-1-propanol;1-o-Chlorophenyl-3-dimethylamino-1-phenylpropan-1-ol;1-Phenyl-1-(o-chlorophenyl)-3-dimethylaminopropanol;1-Phenyl-1-o-chlorophenyl-3-(dimethylamino)-1-propanol | | CAS: | 791-35-5 | | MF: | C17H20ClNO | | MW: | 289.7998 | | EINECS: | 2123409 | | Product Categories: | | | Mol File: | 791-35-5.mol |  |
| | clofedanol Chemical Properties |
| Melting point | 120° | | Boiling point | 429.8±45.0 °C(Predicted) | | density | 1.148±0.06 g/cm3(Predicted) | | pka | 13.03±0.29(Predicted) | | CAS DataBase Reference | 791-35-5 |
| Toxicity | LD50 i.v. in mice: 70 mg/kg (Lorenz) |
| | clofedanol Usage And Synthesis |
| Originator | Detigon,Bayer,W. Germany,1958 | | Uses | (±)-Chlophedianol is an inhalation eutectic compound, used for treatment of respiratory diseases.Also, used in preparation of Deuterated morphine derivatives useful in treatment of pain or as as antitussive agents with reduced risk of possibility of drug abuse. | | Definition | ChEBI: Clofedanol is a diarylmethane that is 2-chlorophenyl(phenyl)methane substituted on the methane carbon by a 2-(dimethylamino)ethyl group. Used in the treatment of dry cough, it suppresses the cough reflex by a direct effect on the cough centre in the medulla of the brain. It has a role as an antitussive. It is a diarylmethane and a tertiary amino compound. It is a conjugate base of a clofedanol(1+). | | Manufacturing Process | This compound may be produced by reacting o-chlorobenzophenone with
acetonitrile in the presence of sodium amide or another strongly basic
condensing agent, to form the nitrile of beta-phenyl-beta-o-chlorophenyl-hydracrylic acid, which is then hydrogenated to yield 1-phenyl-1-o-chlorophenyl-3-aminopropanol-1. The latter intermediate compound is
subsequently dimethylated with an agent such as methyl sulfate to provide
the desired end product 1-o-chlorophenyl-1-phenyl-3-dimethylaminopropanol. | | Therapeutic Function | Antitussive |
| | clofedanol Preparation Products And Raw materials |
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