KELATORPHAN
| 中文名称 | KELATORPHAN |
|---|---|
| 中文同义词 | 化合物 T15652 |
| 英文名称 | Kelatorphan |
| 英文同义词 | Kelatorphan;N-[(R)-4-(Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-alanine;OJCFZTVYDSKXNM-GXSJLCMTSA-N;(2S)-2-[[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]amino]propanoic acid;L-Alanine, N-[(2R)-4-(hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]- |
| CAS号 | 92175-57-0 |
| 分子式 | C14H18N2O5 |
| 分子量 | 294.3 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 92175-57-0.mol |
| 结构式 |  |
KELATORPHAN 性质
| 密度 | 1.301±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 3.58±0.10(Predicted) |
Enkephalin degrading enzyme.
The administration of Kelatorphan alone (50 μg) could result in a strong increase of intact [ 3 H]enkephalin content corresponding to 80±11% of total recovered radioactivity. In normal awake rats, Kelatorphan (10±20 mg/kg i.v.) increases minute-volume. The increase in ventilation is due to a dose-dependent increase in breathing frequency. In arthritic rats Kelatorphan (20 mg/kg i.v.) increases ventilation and there is no significant difference between arthritic and non-arthritic rats. In pentobarbital-anesthetized rats, a slight (116%) but significant increase of respiration is also produced by Kelatorphan (20 mg/kg, n=6) 10±15 min after administration. The effects of Kelatorphan are not antagonized by a pretreatment with a small dose of naloxone (0.2 mg/kg i.v., 15 min before Kelatorphan), but a larger dose (1 mg/kg) significantly antagonized Kelatorphan (20 mg/kg) at 5 and 10 min in awake rats.