安五脂素
| 中文名称 | 安五脂素 |
|---|---|
| 中文同义词 | 安五脂素 (安五酯素);ANWULIGAN 安五酯素;安五酯素;安五脂素;安五脂素, 来源于五味子;安五脂素, >98%;安五脂素标准品;安五脂素对照品 |
| 英文名称 | Anwuligan |
| 英文同义词 | Anwuligan;4-[(2S,3R)-4-(1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol;Macelignan;Phenol,4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-diMethylbutyl]-2-Methoxy-;Calophyn;ANWULIGNAN;Anwuligan, 98%, from Schisandra chinensis;4-(2S,3R)-4-(1,3-benzodioxol-5-yl-2-3-dimetybty]-2_methoxyphenol |
| CAS号 | 107534-93-0 |
| 分子式 | C20H24O4 |
| 分子量 | 328.4 |
| EINECS号 | |
| 植物来源 | 五味子 |
| 相关类别 | 中药对照品;标准品;植物提取物;对照品;分析试剂标准品;对照品-中药对照品;木脂素;标准品 -中药标准品;标准品，对照品;化合物 |
| Mol文件 | 107534-93-0.mol |
| 结构式 |  |
安五脂素 性质
| 熔点 | 70-71℃ |
|---|---|
| 沸点 | 467.0±40.0 °C(Predicted) |
| 密度 | 1.159 |
| 闪点 | 236℃ |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥30mg/mL（91.35mM） |
| 酸度系数(pKa) | 10.19±0.20(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色 |
| LogP | 5.220 (est) |
|
COX-2
|
Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm 2 , reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells.
Cell Viability Assay
| Cell Line: | Hacat cells |
| Concentration: | 1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM |
| Incubation Time: | 72 hours |
| Result: | Induced cell death by UVB irradiation at 30 mJ/cm 2 from 10 μM. |
Western Blot Analysis
| Cell Line: | Hacat cells |
| Concentration: | 0.1 μM; 0.5 μM;1 μM |
| Incubation Time: | 24 hours |
| Result: | Reduced UVB-induced COX-2 expression in cells. |
Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ- db/db mice.
| Animal Model: | Male C57BL/KsJ- db/db mice |
| Dosage: | 15 mg/kg |
| Administration: | Oral administration; 15 mg/kg; every day for three weeks |
| Result: | Significantly reduced the blood glucose levels in mice. |
药理药效:抗肿瘤、凝血
安全信息
| 海关编码 | 29329990 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N0064 | Macelignan | 1 mg | 685元 | |
| 2024/01/25 | HY-N0064 | 安五脂素 Macelignan | 107534-93-0 | 5mg | 1500元 |