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| | 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Basic information |
| | 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Chemical Properties |
| Melting point | 293-295 °C | | density | 1.42g/cm3 at 20℃ | | vapor pressure | 0.002-0.005Pa at 20-25℃ | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly, Heated), Methanol (Very Slightly, Heated), Water (Slightly, Heated) | | form | Solid | | color | White to Off-White | | LogP | -0.84 at 20℃ and pH7 | | CAS DataBase Reference | 84163-13-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2934990002 |
| | 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Usage And Synthesis |
| Uses | 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride (Risperidone EP Impurity M; Paliperidone USP Related Compound B) is a novel antiproliferative agent. |
| | 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Preparation Products And Raw materials |
| Raw materials | 1-Piperidinecarboxaldehyde, 4-(6-fluoro-1,2-benzisoxazol-3-yl)--->1-Piperidinecarboxaldehyde, 4-[(2,4-difluorophenyl)(hydroxyimino)methyl]--->1-FORMYL-PIPERIDINE-4-CARBONYL CHLORIDE-->4-(2,4-DIFLUORO-BENZOYL)-PIPERIDINE-1-CARBALDEHYDE-->2,4-Difluorobenzaldehyde-->1-Methylpiperdin-4-ylmagnesium chloride, 0.50 M in THF-->2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime-->2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride-->Isonipecotic acid-->1,3-Difluorobenzene | | Preparation Products | Risperidone-->Iloperidone-d3-->3-(1-(3-CHLOROPROPYL)PIPERIDIN-4-YL)-6-FLUOROBENZO[D]ISOXAZOLE-->Paliperidone Palmitate |
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