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Oxaliplatin

Oxaliplatin Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:61825-94-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Target molecule Corp.  Gold
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Products Intro:Product Name:Oxaliplatin
CAS:61825-94-3
Purity:99% Package:2mg;5mg;20mg;50mg
Company Name: J & K SCIENTIFIC LTD.  
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Products Intro:Product Name:Oxaliplatin
CAS:61825-94-3
Purity:95% Package:250MG,50MG
Company Name: Sichuan Ruibo Technology Co., Ltd  
Tel:+86-817-5586080
Email:sales@scrbkj.com
Products Intro:Purity:99%
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
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Products Intro:Product Name:Oxaliplatin
CAS:61825-94-3
Package:100Mg Remarks:O0372
Oxaliplatin Basic information
Indications and Usage Mechanisms of Action Adverse Effects
Product Name:Oxaliplatin
Synonyms:[SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM;OXALIPLATIN;trans-l-diaminocyclohexane oxalatoplatinum;(1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr;1-ohp;oxalato(1r,2r-cyclohexanediammine)platinum(ii);oxalatoplatin;oxalatoplatinum
CAS:61825-94-3
MF:C8H14N2O4Pt
MW:397.29
EINECS:274-613-9
Product Categories:Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;Antineoplastic;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;Amines;Heterocycles;chemical reaction,pharm,electronic,materials;PRAXILENE;Inhibitors
Mol File:61825-94-3.mol
Oxaliplatin Structure
Oxaliplatin Chemical Properties
storage temp. Store at +4°C
form solid
Water Solubility Soluble in water with heating and/or sonication
Merck 14,6912
Stability:Stable. Store cool. Incompatible with oxidizing agents.
InChIKeyZROHGHOFXNOHSO-BNTLRKBRSA-L
Safety Information
Hazard Codes Xn,Xi
Risk Statements 36/37/38-40-42/43
Safety Statements 26-36
RIDADR 2811
WGK Germany 3
RTECS TP2275850
HazardClass 6.1(a)
PackingGroup II
MSDS Information
ProviderLanguage
SigmaAldrich English
Oxaliplatin Usage And Synthesis
Indications and UsageOxaliplatin, also called Eloxatin or Eloxatine, is a platinum derivative.
Used clinically to treat patients with metastatic colorectal cancer after failure of fluorouracil treatment, can be used alone or in combination with 5-fluorouracil. It is the third-generation platinum antitumor compound after cisplatin and carboplatin, and so far the only platinum-based drug with significant effectiveness against colorectal cancer. It also inhibits proliferation of ovarian cancer and melanoma cell lines.
Mechanisms of ActionActs on DNA through production of alkylating conjugates, inhibiting its synthesis and reproduction by forming interchain and intrachain cross-links.
Adverse Effects
  • Hematopoietec system: Oxaliplatin has a certain blood toxicity. When used alone, it can cause the following adverse effects: anemia, leukopenia, neutropenia, thrombocytopenia, sometimes reaching grade 3 or 4. Increases hematologic toxicities such as neutropenia and thrombocytopenia when combined with 5-fluorouracil.
  • Digestive system: can cause nausea, vomiting, and diarrhea when used alone. These symptoms can sometimes be very serious. These side effects are significantly exacerbated when used in combination with 5-fluorouacil. Use of prophylactic and/or therapeutic antiemetic drugs is recommended.
  • Nervous system: Peripheral sensory neuropathy characterized by peripheral neuritis. Sometimes associated with convulsions and sensory disturbances in the mouth, upper respiratory tract, and upper GI tract.
Chemical PropertiesWhite Crystalline Solid
UsesA antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA
UsesThird generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
Usesvasodilator
UsesA potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines
UsesOxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.
Biological ActivityAntitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (cis-Diaminodichloroplatinum ) and shows antitumor activity in cell lines with acquired cisplatin resistance.
Oxaliplatin Preparation Products And Raw materials
Raw materialsSilver nitrate-->Dipotassium rabdosiin Rabdosiin-->1,2-Diaminocyclohexane
Tag:Oxaliplatin(61825-94-3) Related Product Information
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