N,N,N',N'-四(2-吡啶甲基)乙二胺

N,N,N',N'-四(2-吡啶甲基)乙二胺

中文名称N,N,N',N'-四(2-吡啶甲基)乙二胺
中文同义词N,N,N',N'-4(2-吡啶甲基)乙二胺;N,N,N',N'-四(2-吡啶甲基)乙二胺,室温保存即可;1,2-乙烷二胺, N,N,N',N'-四(2-吡啶基甲基)-;N,N,N',N'-四(2-吡啶甲基)乙二胺;N,N,N',N'-四(2-吡啶甲基)乙二胺;N,N,N',N'-四-(2-吡啶基甲基)乙二胺;N,N,N',N'-四KIS-(2-吡啶基甲基)乙二胺;N,N,N',N'-四-(2-吡啶基甲基)乙二
英文名称TPEN
英文同义词N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-Ethanediamine;TPEN;1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-;1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-, (oc-6-11)-;N1,N1,N2,N2-tetrakis(pyridin-2-ylMethyl)ethane-1,2-diaMine;N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
CAS号16858-02-9
分子式C26H28N6
分子量424.54
EINECS号
相关类别杂环化合物;合成材料中间体;聚合试剂;其它;Heterocycles;Inhibitors;Apoptosis;Aromatics;Chelating Agents & Ligands;Apoptosis Inducers
Mol文件16858-02-9.mol
结构式N,N,N',N'-四(2-吡啶甲基)乙二胺 结构式

N,N,N',N'-四(2-吡啶甲基)乙二胺 性质

熔点110-112 °C
沸点530.56°C (rough estimate)
密度1.3893 (rough estimate)
折射率1.4570 (estimate)
储存条件Sealed in dry,2-8°C
溶解度溶于DMSO(高达10mg/ml)。
酸度系数(pKa)5.19±0.12(Predicted)
形态棕褐色固体
颜色灰白色或棕褐色
BRN4211982
稳定性可在-20°C下的DMSO中的溶液储存长达3个月。
CAS 数据库16858-02-9(CAS DataBase Reference)

N,N,N',N'-四(2-吡啶甲基)乙二胺 用途与合成方法

TPEN (TPEDA) 是一种可透过细胞的重金属螯合剂,可通过负调控细胞内 NO 和 Zn2+ 信号转导来诱导NB4细胞凋亡。TPEN(TPEDA)可能是APL (acute promyelocytic leukemia) 的潜在治疗策略之一。
TargetValue
NO
()

Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. TPEN, a cell-permeable chelator for heavy metal cations with a low affinity for Ca 2+ . In cells stimulated with 10 or 30 μM cadmium chloride, the addition of TPEN at 3 hr after exposure significantly decreases the elevated fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380) induced by 10 or 30 μM cadmium chloride, respectively), suggesting that a cadmium chloride-induced increase in the fura-2 fluorescence ratio is dependent on an increase in intracellular heavy metal cations but not intracellular Ca 2+ . TPEN is a metal chelator, which targets colon cancer cells through redox cycling of copper. TPEN reduces cell viability in a dose- and time-dependent manner. TPEN-induced cell death is also dependent on the redox cycling of copper since the copper chelator neocuproine inhibited DNA damage and reduced pChk1, γ-H2AX, and ATM protein expression. Cell death by low TPEN concentrations, involved ATM/ATR signaling in all 3 cell lines, since pre-incubation with specific inhibitors of ATM and DNA-PK led to the recovery of cells from TPEN-induced DNA damage.

安全信息

危险品标志Xi
危险类别码36/37/38
安全说明26-36
WGK Germany3
F8-10-23
海关编码29333990

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-100202N,N,N',N'-四(2-吡啶甲基)乙二胺
TPEN
16858-02-950mg550元
2024/01/25HY-100202N,N,N',N'-四(2-吡啶甲基)乙二胺
TPEN
16858-02-910mM * 1mLin DMSO605元
"N,N,N',N'-四(2-吡啶甲基)乙二胺"相关产品信息
硫酸博莱霉素 艾地苯醌 艾曲波帕 去铁酮 N-乙基乙二胺 一水硫酸锌 N,N,N',N'-四(2-吡啶甲基)乙二胺 二甲基吡啶胺 2-氨甲基吡啶 N-甲基-1-吡啶-2-甲胺
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