普罗加比
| 中文名称 | 普罗加比 |
|---|---|
| 中文同义词 | 氟柳双胺;哈罗加比;普罗加比;卤加比;4-[[(4-氯苯基)(5-氟-2-羟基苯基)亚甲基]氨基]丁酰胺;4-[[(Z)-(4-氯苯基)-(3-氟-6-氧代-1-环己-2,4-二烯亚基)甲基]氨基]丁酰胺;化合物 T16581;化合物PROGABIDE |
| 英文名称 | Progabide |
| 英文同义词 | progabide;BUTANAMIDE, 4-[[(4-CHLOROPHENYL)(5-FLUORO-2-HYDROXYPHENYL)METHYLENE]AMINO]-;Halogabide;(E)-4-((4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methyleneamino)butanamide;4-[[(Z)-(4-Chlorophenyl)-(3-fluoro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]butanamide;4-[[(4-Chlorophenyl)(5-fluoro-2hydroxyphenyl)methylene]amino]butanamide;C-abren(e);SL-76．002 |
| CAS号 | 62666-20-0 |
| 分子式 | C17H16ClFN2O2 |
| 分子量 | 334.77 |
| EINECS号 | 263-679-4 |
| 相关类别 | 抗癫痫药;药物;中枢神经系统用药;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 62666-20-0.mol |
| 结构式 |  |
普罗加比 性质
| 熔点 | 133-135°; mp 142.5° (Kaplan, J. Med. Chem.) |
|---|---|
| 沸点 | 525.4±50.0 °C(Predicted) |
| 密度 | 1.2822 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 氯仿（微溶超声处理）、DMSO、甲醇（微溶超声处理） |
| 形态 | 固体 |
| 酸度系数(pKa) | pKa 3.41 ± 0.04(0.4% MeOH,t=37,Iundefined)(Approximate) |
| 颜色 | 浅黄色至厚黄色 |
| 水溶解性 | 37.16mg/L(37 ºC) |
| CAS 数据库 | 62666-20-0 |
GABA receptor
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide.
安全信息
| 毒性 | LD50 i.p. in mice: 900 mg/kg (Kaplan) |
|---|
普罗加比 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-A0173 | 普罗加比 Progabide | 62666-20-0 | 5 mg | 600元 |
| 2024/01/25 | HY-A0173 | 普罗加比 Progabide | 10 mM * 1 mLin DMSO | 660元 |