L-Leucyl-L-Leucine methyl ester (hydrochloride)
| 中文名称 | L-Leucyl-L-Leucine methyl ester (hydrochloride) |
|---|---|
| 中文同义词 | (S)-2-((S)-2-氨基-4-甲基戊酰胺基)-4-甲基戊酸甲酯盐酸盐;化合物LEU-LEU-OME HYDROCHLORIDE |
| 英文名称 | L-Leucyl-L-Leucine methyl ester (hydrochloride) |
| 英文同义词 | L-Leucyl-L-Leucine methyl ester (hydrochloride);methyl (2S)-2-[(2S)-2-amino-4-methylpentanamido]-4-methylpentanoate hydrochloride;Leu-Leu-ome hydrochloride;H-Leu-leu-OMe hydrochloride;L-Leucine, L-leucyl-, methyl ester, monohydrochloride;L-Leucyl-L-Leucine methyl ester;lymphocytes,leukocytes,monocytes,pathway,LLeucylLLeucine methyl ester hydrochloride,LLOMe,inhibit,polymorphonuclear,stress,Leu-Leu methyl ester,cytotoxic,Inhibitor,L Leucyl L Leucine methyl ester hydrochloride,Endogenous Metabolite,endolysosomal |
| CAS号 | 6491-83-4 |
| 分子式 | C13H27ClN2O3 |
| 分子量 | 294.81808 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 6491-83-4.mol |
| 结构式 |  |
L-Leucyl-L-Leucine methyl ester (hydrochloride) 性质
| 熔点 | 177-181°C |
|---|---|
| 储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
| 溶解度 | DMSO（少许）、水（少许） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride 是人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，可选择性消除具有细胞毒性潜能的淋巴细胞。L-Leucyl-L-Leucine methyl ester hydrochloride 也可以诱导溶酶体途径应激。
L-Leucyl-L-Leucine methyl ester (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells.
L-Leucyl-L-Leucine methyl ester (10-250 μM; 15 min) is converted to a CCI
3
COOH-insoluble product by CD4
-
lymphocytes.