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Topotecan

Topotecan Suppliers list
Company Name: SiChuang NanBu Honesty Technology Co., Ltd.  
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Products Intro:Product Name:Topotecan hydrochloride
CAS:123948-87-8
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Products Intro:Product Name:Topotecan
CAS:123948-87-8
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Products Intro:Product Name:Topotecan
CAS:123948-87-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Chembest Research Laboratories Limited  
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Products Intro:Product Name:Topotecan
CAS:123948-87-8
Remarks:C14281
Company Name: Beijing Ouhe Technology Co., Ltd  
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Products Intro:Product Name:Topotecan
CAS:123948-87-8
Purity:98% Package:10g;50g;100g;250g;500g
Topotecan Basic information
Camptothecin anticancer drugs Uses Production methods
Product Name:Topotecan
Synonyms:hycamptamine;HYDROGEN CHLORIDE, BUTANOL REAGENT;HYDROGEN CHLORIDE GAS;HYDROGEN CHLORIDE, METHANOL REAGENT;HYDROGEN CHLORIDE, METHANOL REAGENT 10;HYDROGEN CHLORIDE, METHANOL REAGENT 5;HYDROCHLORIC ACID,1.1M;HYDROCHLORIC ACID, 1N
CAS:123948-87-8
MF:C23H23N3O5
MW:421.45
EINECS:231-595-7
Product Categories:APIs;API
Mol File:123948-87-8.mol
Topotecan Structure
Topotecan Chemical Properties
Melting point −114 °C(lit.)
Boiling point >100 °C(lit.)
density 1.2 g/mL at 25 °C(lit.)
vapor density 1.3 (vs air)
vapor pressure 613 psi ( 21.1 °C)
Fp 12 °C
storage temp. 2-8°C
solubility H2O: soluble
form liquid
color yellow
CAS DataBase Reference123948-87-8(CAS DataBase Reference)
Safety Information
Hazard Codes T,C,F,Xi
Risk Statements 36/37/38-67-35-20-11-34-48-46-36
Safety Statements 26-45-36/37/39-37/39-36-22-24/25-16-7
RIDADR UN 3286 3/PG 2
WGK Germany 2
RTECS MW4025000
3
HazardClass 8
PackingGroup II
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Topotecan Usage And Synthesis
Camptothecin anticancer drugsCamptothecin anticancer drugs are alkaloids or derivatives of them after the structure transformation raised from deciduous plant Davidia involucrata Camptotheca acuminate seed or root bark. Clinical application of them mainly includes camptothecin,hydroxycamptothecin, topotecan and irinotecan.
Topotecan is a water-soluble semi-synthetic derivative of camptothecin,it is a topoisomerase I inhibitor, inhibiting DNA single strand DNA scission reconnect to damage DNA, its cytotoxicity occurs in cancer cell division S phase, it is an s phase cell cycle specific drug . In vivo it is a two-compartment model,it can be quickly distributed to the liver, kidneys and other parts , of a single intravenous infusion 1.5mg/m2 every 30 minutes , t1/2αis 4.1 to 8.1 minutes, plasma protein binding rate is 6.6%~21.3%,it can go into the cerebrospinal fluid. Most of it is excreted by the kidneys, a small part of it is excreted by the bile, within 12 hours, 90% of it is excreted.Clearance rate of renal dysfunction decreases.it is clinically used for the treatment of small cell lung cancer (SCLC), and advanced ovarian cancer, because it can penetrate the blood-brain barrier ,it has a certain effect on the central nervous system cancer and brain metastases. Usage: every single drug dose 1.2mg/m2 intravenous infusion once a day, once every 5 days, 21 days is 1 cycle, there is the need to reduce the dose when in combination with other anticancer drugs. The main adverse events are hematologic toxicity, white blood cells, platelets and hemoglobin decrease; non-hematologic toxicity adverse events are loss of appetite, nausea, vomiting, hair loss, stomatitis, diarrhea, headache, fever, constipation, transient elevated transaminase; occasionally breathing difficulties, hematuria, andelectrocardiogram abnormalities.
Severe bone marrow suppression are hanged. Monitor the blood and adjust the dose in accordance with changes in blood during the treatment , if necessary, granulocyte colony stimulating factor (G-CSF), and transfusion of blood components may be given .
The above information is edited by the chemicalbook of Tian Ye.
UsesAnti-cancer drugs.It can be used alone for the treatment of initially or continuously ineffective chemotherapy metastatic ovarian cancer.
Production methodsCompound (I) with 37% formaldehyde and 40% dimethylamine,after aminomethylation in acetic acid, produces the product.
Chemical PropertiesOff-white Cryst
Usesantineoplastic;DNA topoisomerase type 1 inhibitor
DefinitionChEBI: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Topotecan Preparation Products And Raw materials
Raw materialsDimethylamine
Tag:Topotecan(123948-87-8) Related Product Information
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