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Atropine

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Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682; +8618874586545
Email: bruce@xrdchem.cn
Products Intro: Product Name:Atropine sulfate 51-55-8
CAS:51-55-8
Purity:98% Package:1KG;20USD
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
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Products Intro: Product Name:Atropine
CAS:51-55-8
Company Name: Syntechem Co.,Ltd  
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Products Intro:Product Name:8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
CAS:51-55-8
Purity:97% Package:1g;5g;25g;100g;250g;1kg;5kg;10kg;25kg Remarks:we offer low price custom synthesis and contract manufacturing
Company Name: Hangzhou Yuhao Chemical Technology Co., Ltd  
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Products Intro:Product Name:Atropine
CAS:51-55-8
Company Name: Spectrum Chemical Manufacturing Corp.  
Tel:021-67601398,18616765336,QQ:3475911745
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Products Intro:Product Name:Atropine, USP
CAS:51-55-8
Purity:USP Package:100GM Remarks:AT100

Lastest Price from Atropine manufacturers

  • Atropine
  • US $800.00 / KG
  • 2018-03-06
  • CAS:51-55-8
  • Min. Order: 1KG
  • Purity: 99.9%
  • Supply Ability: 10000
Atropine Basic information
Overview Chemical properties Pharmacokinetics Side effects Production Category Toxicity grade Acute Toxicity Flammability Hazard characteristics Storage and transportation Extinguishing agent
Product Name:Atropine
Synonyms:Benzeneaceticacid, α-(hydroxymethyl)-(3-endo)-;Hyoscyamine, Tropine tropate, endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester;(±)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester;Atropine,99%;endo-(±)-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester;Atropine solution ;ATROPINE;(+/-)-HYOSCYAMINE
CAS:51-55-8
MF:C17H23NO3
MW:289.37
EINECS:200-104-8
Product Categories:ATROPISOL;Inhibitors;Pharmaceutical;Alkaloids;Biochemistry;Tropane Alkaloids
Mol File:51-55-8.mol
Atropine Structure
Atropine Chemical Properties
Melting point 115-118 °C
Fp 2℃
storage temp. ?20°C
solubility H2O: 2 mg/mL
form powder
pka9.7(at 21℃)
color white
Sensitive Light Sensitive
Merck 14,875
InChIKeyRKUNBYITZUJHSG-SPUOUPEWSA-N
CAS DataBase Reference51-55-8(CAS DataBase Reference)
NIST Chemistry ReferenceAtropine(51-55-8)
EPA Substance Registry SystemBenzeneacetic acid, .alpha.-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[ 3.2.1]oct-3-yl ester(51-55-8)
Safety Information
Hazard Codes T+,Xn,F
Risk Statements 26/28-36/37/38-20/21/22-36-11
Safety Statements 25-45-36-26-36/37-16
RIDADR 1544
WGK Germany 3
RTECS CK0700000
8-10-23
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29399900
Hazardous Substances Data51-55-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
Atropine Usage And Synthesis
OverviewAtropine is an alkaloid extracted from the Atropa bell-adonna, Datura stramonium, or Hyosc-yamus niger. What is naturally occurring is the unstable L-hyoscyamine, which can be converted to the stable racemate atropine after chemical treatment. It can also be chemically synthesized; what is commonly used in its sulfate. It appears as white crystalline powder, being odorless, bitter, and soluble in water and alcohol. Upon contact with alkaline drugs, it can cause decomposition. Atropine blocks the M-choline receptor, thereby antagonizing the M-like effect of acetylcholine or its quasi-drug (muscarinic effect).
The main effect is as follows:
  1. Relax the smooth muscle: This product has the role of relaxation of many visceral smooth muscle; it has remarkable relaxation effect on over-activity or spammed smooth muscle, while having less effect on the normal activity of the smooth muscle.
  2. Inhibition of glandular secretion: inhibit the glandular secretion by blocking the M-choline receptor. The most obvious effect occurs on salivary glands and sweat glands. It can also greatly reduce the secretion of lacrimal glands and respiratory glands, but the impact on gastric acid secretion is smaller.
  3. The effect on the eye: atropine, through blocking the pupil sphincter and ciliary muscle M-choline receptors, is manifested as mydriasis, increased intraocular pressure and adjust paralysis. All three effects have important clinical implications.
  4. The effect on the cardiovascular: a larger dose (1 ~ 2mg) atropine can get rid of the inhibitory effect of the vagus nerve on the heart, thus accelerating the heart rate. Large doses can dilate the skin and visceral blood vessels, and relieve arteriolar spasm. Its mechanism of dilating blood vessels and relieving small vasospasm is unknown.
  5. Excitement of the central nervous system: high-dose cause irritability, prolonged talk and delirium. Poisoning dose (more than 10mg) can produce hallucinations, disorientation, involuntary exercise and convulsions.
Chemical propertiesIt appears as white crystalline powder, odorless, tasteless. Mp 114-116°C; sublimation at 93-110 °C under high vacuum. The solubility of this product in each solvent: 80 ℃ hot water (1:90), ethanol (1: 2), chloroform (1: 1), ether (1:25), dissolved in benzene and dilute acid solution. Low toxicity, LD50 (rat, oral): 622mg / kg.
PharmacokineticsIt can be quickly absorbed by the gastrointestinal tract after oral administration and quickly distributed to the body tissue. It can also penetrate through the placenta into the fetal circulation. Clinical studies have shown that after intramuscular injection of 2 mg, 85 ~ 88% is subject to urine excretion within 24 hours. Approximately 5% of them were found in their prototypes and 33% of their metabolites; only a small amount was excreted in feces and other secretions.
Side effectsDry mouth, blurred vision, heart palpitations, dry skin and constipation. High-dose poisoning switches excitement into inhibition, causing coma and respiratory paralysis and death.
ProductionIt can be extracted from the root of Solanaceae Scoparia Anisodus tanguticus or Himalayan Scoparia; can also be obtained by artificial synthesis.
Belladonna leaf is extracted out of the scopolamine (L-body), followed by racemization, recrystallization to make it.
Categorytoxic substances
Toxicity gradehighly toxic
Acute ToxicityOral - Rat LD50: 500 mg / kg; Oral - Mouse LD50: 75 mg / kg
Flammability Hazard characteristicsFlammable; Combustion produces toxic nitrogen oxide fumes; Patient medication side effects: Visual changes; Dilated pupils, Muscle weakness.
Storage and transportationVentilated, dry and low temperature; Separated from foodstuffs in storehouse
Extinguishing agentdry powder, foam, sand, carbon dioxide, water mist
Chemical Propertieswhite Crystalline powder
Usesanticholinergic, mydriatic
Atropine Preparation Products And Raw materials
Preparation ProductsAtropine sulfate monohydrate
Tag:Atropine(51-55-8) Related Product Information
HYOSCYAMINE N-OXIDE HYDROCHLORIDE L-Hyoscyamine ATROPINE ISOPROPYLBROMIDE Atropine Methylparaben DL-Thioctic acid 2-Hydroxyphenylacetic acid Phenylacetic acid Testosterone phenylacetate Kresoxim-methyl Methyl bromide Methyl acrylate 4-Hydroxyphenylacetic acid 4-Methoxyphenylacetic acid Atropine monohydrate sulfate salt,ATROPINE SULFATE, MONOHYDRATE USP,Atropine Sulfate Hydrate,Atropine sulphate monohydrate, 98+%,ATROPINE SULFATE SALT MONOHYDRATE,ATROPINE SULFATE MONOHYDRATE,ATROPINE SULPHATE MONOHYDRATE Methyl Parathion-methyl atropine,sulfate(2:1