吖啶黄
| 中文名称 | 吖啶黄 |
|---|---|
| 中文同义词 | 丫啶黄素/吖啶黄素/吖啶黄/吖黄素/3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶混合物/吖啶素;吖啶黄素(3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶的混合;丫啶黄素;3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶混合物;吖啶黃素;吖啶黄素(3,6-二氨基-10-甲基吖啶盐酸盐和3,6-二氨基吖啶的混合物);吖啶素;吖啶黄素 |
| 英文名称 | ACRIFLAVINE |
| 英文同义词 | 2,8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE;Acriflavine 10;Trypaflavine Neutral;GUANOSINE ULTRA PURE GRADE;4-Acetamino phenol ( APAP );Acriflavine 〔Trypaflavine〕;XANTHACRIDINE;TRYPAFLAVINE FS |
| CAS号 | 8048-52-0 |
| 分子式 | C27H25ClN6 |
| 分子量 | 468.98 |
| EINECS号 | 999-999-2 |
| 相关类别 | 试剂;生化试剂;荧光探针，标记，颗粒和染色;生物化学;各种化学试剂;色素类;生化试剂-色素类;化学试剂;marker;培养基配套试剂;合成材料中间体;化工原料;通用生化试剂-生物染色剂与化学指示剂;染色剂 |
| Mol文件 | 8048-52-0.mol |
| 结构式 |  |
吖啶黄 性质
| 熔点 | 179-181 °C |
|---|---|
| 沸点 | 612.69°C (rough estimate) |
| 密度 | 1.0933 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 在水中的溶解度为0.33g/mL(lit.)(lit.) |
| 形态 | 粉末 |
| 颜色 | 深橙色至棕红色 |
| Merck | 14,123 |
| CAS 数据库 | 8048-52-0(CAS DataBase Reference) |
| EPA化学物质信息 | Xanthacridinum (8048-52-0) |
Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells.
Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis.
安全信息
| 危险品标志 | Xn,N |
|---|---|
| 危险类别码 | 22-37/38-41-50/53-20/21/22-50-36/37/38 |
| 安全说明 | 26-39-60-61-36-37/39-29-36/37/39 |
| 危险品运输编号 | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS号 | AR9660000 |
| 海关编码 | 38249064 |
| 提供商 | 语言 |
|---|---|
|
英文
|
|
|
英文
|