- tert-Butyllithium
-
- $15.00 / 1KG
-
2021-07-13
- CAS:594-19-4
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- tert-Butyllithium
-
- $15.00 / 1KG
-
2021-07-10
- CAS:594-19-4
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Tert-Butyllithium
-
- $1.00 / 1kg
-
2019-07-06
- CAS:594-19-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: Customized
|
| | tert-Butyllithium Basic information |
| Product Name: | tert-Butyllithium | | Synonyms: | TERT-BUTYLLITHIUM;T-BUTYLLITHIUM;tert-Butyllithium (ca. 18% in Pentane, ca. 1.9mol/L);(1,1-dimethylethyl)-lithiu;tert-Butyllithium, 1.5M solution in pentane;tert-butyllithium, nominally 1.5m in n-pentane, packaged under argon in resealable chemseal;TERT-BUTYLLITHIUM 1.5M IN PENTANE;tert-Butyllithium, nominally 1.5M in n-pentane, packaged under Argon in resealable ChemSealTM bottles | | CAS: | 594-19-4 | | MF: | C4H9Li | | MW: | 64.06 | | EINECS: | 209-831-5 | | Product Categories: | metal alkyl | | Mol File: | 594-19-4.mol |  |
| | tert-Butyllithium Chemical Properties |
| Boiling point | 36-40 °C | | density | 0.69 g/mL at 20 °C | | vapor density | ~3 (vs air) | | Fp | 20 °F | | storage temp. | 2-8°C | | form | liquid | | color | slightly cloudy | | Sensitive | Air & Moisture Sensitive | | BRN | 3587204 | | Exposure limits | ACGIH: TWA 1000 ppm
OSHA: TWA 1000 ppm(2950 mg/m3)
NIOSH: IDLH 1500 ppm; TWA 120 ppm(350 mg/m3); Ceiling 610 ppm(1800 mg/m3) | | InChIKey | BKDLGMUIXWPYGD-UHFFFAOYSA-N | | CAS DataBase Reference | 594-19-4(CAS DataBase Reference) | | EPA Substance Registry System | Lithium, (1,1-dimethylethyl)- (594-19-4) |
| | tert-Butyllithium Usage And Synthesis |
| Description | tert-Butyllithium solution (tert-BuLi) is an organolithium compound, used as a strong base in organic chemistry. It facilitates lithium-halogen exchange reaction and also can be employed in the deprotonation of C-H compounds and amines. it has applications in organic synthesis since it is a strong base, capable of deprotonating many carbon molecules, including benzene. tert-Butyllithium is available commercially as hydrocarbon solutions; it is not usually prepared in the laboratory. Its synthesis was first reported by R. B. Woodward in 1941. | | Chemical Properties | tert-Butyllithium is a colorless crystalline solid or colourless to pale yellow solution. It is more reactive than n- or sec-butyllithium and has similar properties. However, it is thermally stable. Dixon and co-workers have heated tert-Butyllithium to 100°C for 20 hr with little decomposition. | | Uses |
- There are no commercial uses of t-butyllithium, but it is used as a polymerization initiator and as a metalating agent in the laboratory.
- Alkylating and metalating agent. Reagent for the introduction of the tert-butyl group.
- tert-Butyllithium (t-BuLi) is the most reactive of the commercially available organolithium reagents. It is supplied as a standard solution in hydrocarbon solvents, usually in a bottle sealed with a septum.
| | Application | tert-Butyllithium solution can be used as a strong base in the synthesis of:
Alkyllithium derivatives form alkyl iodides and diiodoalkanes by halogen-lithium exchange reaction.
Inorganic polymer [(LiMo3Se3)n] from [(InMo3Se3)n] by reductive intercalation method.
Adducts of cinnamic acid (1,3- and 1,4-adducts) by reacting with C-C double of cinnamic acid. | | Preparation | tert-Butyllithium is not sold in large quantities. The
industrial and laboratory preparations are the same: the reaction of t-butyl chloride with
lithium metal in a hydrocarbon solvent. However, tert-Butyllithium is much more difficult to
produce than the other isomeric butyllithium compounds and some special precautions
must be taken to obtain good yields. Principally, the lithium metal must be finely divided
and must contain several percent sodium. It has also been found that t-butyl alcohol in
the butyl chloride is beneficial. The solvent of choice is pentane. Vigorous reflux is necessary for good yield since it apparently helps to remove lithium chloride from the
surface of the metal, and pentane refluxes at about the optimum temperature. If hexane is
used at the same temperature, a significantly lower yield is obtained. |
| | tert-Butyllithium Preparation Products And Raw materials |
|