苦参新醇 A
中文名称 | 苦参新醇 A |
---|---|
中文同义词 | 苦参醇A;苦参新醇 A;苦参新醇A对照品;苦参新醇A标准品;勒奇黄烷酮E;苦参醇A/苦参新醇A;苦参醇A,勒奇黄烷酮E |
英文名称 | Leachianone E |
英文同义词 | Kushenol A;Leachianone E;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)-;(2S)-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one;4H-1-Benzopyran-4-one,2,3-dihydro-5,7-dihydroxy-2-(2-hydroxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-, (2S)- |
CAS号 | 99217-63-7 |
分子式 | C25H28O5 |
分子量 | 408.49 |
EINECS号 | |
植物来源 | 苦参 |
相关类别 | 标准品;植物提取物;对照品;新品推荐;黄酮;标准品,对照品 |
Mol文件 | 99217-63-7.mol |
结构式 |
苦参新醇 A 性质
熔点 | 175-178 °C |
---|---|
沸点 | 581.7±50.0 °C(Predicted) |
密度 | 1.212±0.06 g/cm3(Predicted) |
储存条件 | 4°C, protect from light |
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
形态 | 水晶。 |
酸度系数(pKa) | 7.66±0.40(Predicted) |
IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)
Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC 50 value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM.Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC 50 values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC 50 value of 57.2 μg/ml for BEAS-2B cells.
Cell Viability Assay
Cell Line: | NSCLC cell lines, A549 and NCI-H226Normal human lung epithelial: BEAS-2B |
Concentration: | 0-60 μg/ml |
Incubation Time: | 24 hours |
Result: | Exhibited considerable cytotoxic effects against NSCLC cells. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/01/25 | HY-N2278 | Kushenol A | 1 mg | 3400元 | |
2024/01/25 | HY-N2278 | 苦参新醇 A Kushenol A | 99217-63-7 | 10 mM * 1 mLin DMSO | 7639元 |