五味子丙素
| 中文名称 | 五味子丙素 |
|---|---|
| 中文同义词 | 五味子丙素(标准品);五味子丙素(五味子素C);SCHISANDRIN C 五味子丙素;五味子素C;五味子丙素对照品,;SCHISANDRIN C 五味子丙素 标准品;标准品对照品】SCHISANDRIN C |
| 英文名称 | WUWEIZISU C |
| 英文同义词 | SCHIZANDRIN C;WUWEIZISU C;,8-dimethyl-;cycloocta(1,2-f:3,4-f’)bis(1,3)benzodioxole6,7,8,9-tetrahydro-1,13-dimethoxy-7;(6R,7S,13aS)-5,6,7,8-Tetrahydro-13,14-dimethoxy-6,7-dimethylcycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole;(S)-(-)-Schisandrin C;Schisandrin C (S)-(-)-Schisandrin C;13,14-dimethoxy-6,7-dimethyl-5,6,7,8-tetrahydro[1,3]benzodio... |
| CAS号 | 61301-33-5 |
| 分子式 | C22H24O6 |
| 分子量 | 384.42 |
| EINECS号 | |
| 相关类别 | 中药对照品;植提标准品;中药标准品;标准品;对照品,标准品;分析标准品;植物提取物;对照品;分析试剂标准品;标准品-对照品;标准品-中药标准品;木脂素;标准品 -中药标准品;分析试剂-标准品;标准品，对照品;Miscellaneous Natural Products;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol文件 | 61301-33-5.mol |
| 结构式 |  |
五味子丙素 性质
| 熔点 | 122-123℃ |
|---|---|
| 沸点 | 549.2±50.0 °C(Predicted) |
| 密度 | 1.232 |
| 溶解度 | DMSO：8.33 mg/mL（21.67 mM；需要超声波）H2O：< 0.1 mg/mL（不溶） |
| 形态 | 粉末 |
| 颜色 | 白色 |
| LogP | 5.623 (est) |
Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells.Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells.Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1).
Western Blot Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Decreased the expression of apoptosis related proteins. |
Apoptosis Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced cell apoptosis. |
Cell Cycle Analysis
| Cell Line: | U937 cells |
| Concentration: | 25 μM,50 μM,100 μM |
| Incubation Time: | 48 hours |
| Result: | Induced growth inhibition and G1 arrest of U937 cells. |
Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously.
| Animal Model: | Aβ1-42-induced Alzheimer’s disease mice |
| Dosage: | 15-150 μg/kg |
| Administration: | Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days |
| Result: | Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice. |