羟嗪
| 中文名称 | 羟嗪 |
|---|---|
| 中文同义词 | 2-[2-[4-(4-氯苯基)苯甲基-1-哌嗪基]乙氧基]-乙醇;2-[2-[4-[(4-氯苯基)-苯甲基]哌嗪-1-基]乙氧基]乙醇;羟嗪;羟嗪杂质;2-(2-(4-((4-氯苯基)(苯基)甲基)哌嗪-1-基)乙氧基)乙醇 |
| 英文名称 | Hydroxyzine |
| 英文同义词 | 1-(p-Chloro-a-phenylbenzyl)-4-[2-(2-hydroxyethoxy)ethyl)]piperazine;NSC 169188;1-(p-Chloro-α-phenylbenzyl)-4-[2-((2-hydroxyethoxy)ethyl)]piperazine;2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol;Ethanol, 2-[2-[4-(4-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]- (6CI);Ethanol, 2-[2-[4-(p-chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]- (8CI);Hydroxyzine (base and/or unspecified salts);EQUIPOISE / HYDROXYZINE |
| CAS号 | 68-88-2 |
| 分子式 | C21H27ClN2O2 |
| 分子量 | 374.9 |
| EINECS号 | 200-693-1 |
| 相关类别 | 医药原料;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 68-88-2.mol |
| 结构式 |  |
羟嗪 性质
| 熔点 | 190°C |
|---|---|
| 沸点 | 250 °C(Press: 0.1 Torr) |
| 密度 | 1.1020 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于氯仿（少量）、DMSO（少量）、乙醇（少量）、甲醇（少量） |
| 形态 | 油状至凝胶状 |
| 酸度系数(pKa) | pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate) |
| 颜色 | 无色至黄色 |
| 水溶解性 | < 700 mg/mL |
| BCS Class | 2 |
| NIST化学物质信息 | Hydroxyzine base(68-88-2) |
| EPA化学物质信息 | Hydroxyzine (68-88-2) |
Hydroxyzine，一种苯二氮卓抗组胺剂 (antihistamine)，作为口服活性组胺 H1 受体 (histamine H1-receptor) 和血清素拮抗剂。Hydroxyzine 具有抗焦虑作用，可用于广泛性焦虑障碍的研究。
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H 1 Receptor
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Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.
Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.
安全信息
| 毒害物质数据 | 68-88-2(Hazardous Substances Data) |
|---|---|
| 毒性 | LD50 oral in rat: 840mg/kg |