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Kanamycin sulfate

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CAS:25389-94-0
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CAS:25389-94-0
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Products Intro: Product Name:kanamycin A sulfate
CAS:25389-94-0
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Kanamycin sulfate manufacturers

  • Kanamycin sulfate
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  • $0.00 / 1KG
  • 2024-03-16
  • CAS:25389-94-0
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Kanamycin sulfate
  • Kanamycin sulfate pictures
  • $0.00 / 1g
  • 2024-03-12
  • CAS:25389-94-0
  • Min. Order: 1g
  • Purity: 98% HPLC
  • Supply Ability: 1000kg
  • Kanamycin Sulfate
  • Kanamycin Sulfate pictures
  • $20.00 / 1kg
  • 2023-11-29
  • CAS:25389-94-0
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100tons
Kanamycin sulfate Basic information
Description Reference
Product Name:Kanamycin sulfate
Synonyms:KANAMYCIN MONOSULFATE GAMMA-IRRADIATED*M OLECULAR BI;KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAMYCETIC;KANAMYCIN MONOSULFATE, BPC GRADE;KANAMYCIN SOLUTION 50MG/ML (STERILE*FILT ERED) CELL;KANAMYCIN SULFATE USP(CRM STANDARD);KANAMYCIN SULFATE USP 99%;KANAMYCIN SULFATE, MOLECULAR BIOLOGY GRADE;KANAMYCIN SULFATE CELL CULTURE GRADE 99%
CAS:25389-94-0
MF:C18H38N4O15S
MW:582.58
EINECS:246-933-9
Product Categories:Inhibitors;Amines;Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals;API;KANTREX;antibiotic;Peptide Synthesis/Antibiotics;Aminoglycosides (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Antibiotic Explorer;25389-94-0
Mol File:25389-94-0.mol
Kanamycin sulfate Structure
Kanamycin sulfate Chemical Properties
Melting point 250°C
alpha +112~+123°(D/20℃)(c=1,H2O)(calculated on the dried basis)
density 1.3619 (rough estimate)
refractive index 117.5 ° (C=1, H2O)
storage temp. 2-8°C
solubility H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.
form powder
color white to off-white
PH Range6.5 - 8.5 (1% solution)
Water Solubility Soluble in water at 10mg/ml
Merck 14,5281
InChIKeyOOYGSFOGFJDDHP-KMCOLRRFSA-N
Safety Information
Hazard Codes T
Risk Statements 61
Safety Statements 22-24/25-45-53
WGK Germany 3
RTECS NZ3225030
HS Code 29419020
ToxicityLD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser)
MSDS Information
ProviderLanguage
Kanamycin A monosulfate English
SigmaAldrich English
Kanamycin sulfate Usage And Synthesis
DescriptionIt has been well known as desirable antibiotics, which shows an obvious curative effect on serious infections caused by gram-negative bacteria such as Escherichia coil, Klebsiella, Proteus, Pneumonia, Enterobacter aerogenes and Shigella. Clinically, this substance is mainly used for infections caused by sensitive bacteria including pulmonary infection, urinary tract infection, biliary tract infection, sepsis, and abdominal cavity infection. For example, the effective antibacterial activity of kanamycin sulfate has been demonstrated by the treatment of acute gonorrheal urethritis in men, showing that a single parenterally administered dose of 2 mg of kanamycin sulfate cured 144 (93%) of 155 men with acute gonorrheal urethritis.1 Moreover, kanamycin sulfate was found to be a valuable drug in the treatment of serious infections in infants and children through an analysis of 140 cases treated during a two-year period.2
Reference
  1. JE Fischnaller; AH Pedersen; AR Ronald; P Bonin; Tronca, E., Kanamycin sulfate in the treatment of acute gonorrheal urethritis in men. The Journal of the American Medical Association 1968, 203, 909-912.
  2. MD Yow; Tengg, N., The use of kanamycin sulfate as a therapeutic agent for infants and children. An analysis of 140 cases treated during a two-year period. Journal of Pediatrics 1961, 58, 538-547.
DescriptionKanamycin was found by Umezawa et al. in the culture broth of Streptomyces kanamyceticus in 1957. It is produced with other components, kanamycins B (bekanamycin) and C, which are also separated during the purification. The compound shows much lower toxicity than the earlier aminoglycosides, streptomycin and neomycin, and strong activity against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium. Kanamycin has been used clinically for treatment of such serious infections as dysentery, salmonellosis, and tuberculosis.
Chemical PropertiesOff-white powder
OriginatorKantrex,Bristol,US,1958
UsesKanamycin sulfate is an antibacterial agent similar to neomycin.
UsesAntibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.
UsesKanamycin monosulfate, is used as an aminoglycoside antibiotic. Kanamycin can be used as a selection agent in several types of isolation media.Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100mg/mL.
DefinitionA broadspectrum antibiotic.
Manufacturing ProcessAs described in US Patent 2,931,798, Streptomyces kanamyceticus (K2-J) was first cultured in shake flasks in the following media: (a) 0.75% meat extract, 0.75% peptone, 0.3% NaCl, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol; or (b) 2.0% soybean meal, 0.05% KCl, 0.05% MgSO4 · 7H2O, 0.5% NaCl, 0.2% NaNO3, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol. The initial pH of all media was adjusted to 7.0. After 24 to 48 hours shaking in some cases the pH decreased to about 6.0 to 6.8, but from 72 to 120 hours the pH rose and became 7.5 to 8.6. The production of kanamycin was apparent after 48 hours and, depending on the media; the maximum production was found after 72 to 120 hours.
The yield was highest with starch or dextrin, intermediate and about the same with sucrose, glucose, maltose and lactose and poorest with glycerol. Kanamycin was produced by media containing soybean meal, peanut meal, cottonseed meal, corn steep liquor, peptone, yeast extract or meat extract, with or without sodium nitrate. Commercially available soybean meal was recognized to be one of the best nitrogen sources. The addition of corn steep liquor, peptone, yeast extract or nitrate to the soybean meal promoted the production of kanamycin.
The brownish white kanamycin (5 g) was dissolved in 50 ml of 60% aqueous methanol, insoluble material was removed and to the filtrate 40 ml of 60% aqueous methanol containing 2,000 mg of ammonium sulfate was added, and the precipitated kanamycin sulfate was collected, washed with 50 ml of 80% aqueous methanol, and dried. Thus, 4.5 g of kanamycin sulfate was obtained as a light brownish powder.
Brand nameKlebcil (King).
Therapeutic FunctionAntibacterial
General DescriptionKanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 2 mL/L.
Biological Activitysoluble in water at 50mg/ml recommend our ultra pure, nuclease free water, ab02123 typically used at 100mg/ml for cell culture protect from moisture store: 2-8°c.
Biochem/physiol ActionsMode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
storageRoom temperature
Kanamycin sulfate Preparation Products And Raw materials
Raw materialsEthanol-->Ammonium chloride-->Sodium bisulfite-->Sodium nitrate-->Zinc sulphate-->FERROUS SULFATE-->SOYBEAN MEAL-->Dextrin
Tag:Kanamycin sulfate(25389-94-0) Related Product Information
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