六羟黄酮/栎草亭 CAS#: 90-18-6

六羟黄酮/栎草亭

生物活性靶点体外研究体内研究用途与合成方法 MSDS 六羟黄酮/栎草亭价格(试剂级) 上下游产品信息

中文名称	六羟黄酮/栎草亭
中文同义词	六羟黄酮/栎草亭;栎草亭,槲皮万寿菊素;栎草亭;3,3',4',5,6,7-六羟基黄酮;槲皮万寿菊素栎草亭;六羟黄酮;六羟基黄酮
英文名称	3,3',4',5,6,7-HEXAHYDROXYFLAVONE
英文同义词	QUERCETAGIN;QUERCETAGENIN;QUERCETAGETIN;3,3',4',5,6,7-HEXAHYDROXYFLAVONE;3,5,6,7,3',4'-HEXAHYDROXYFLAVONE;2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4-benzopyrone;2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one;3,5,6,7-Tetrahydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one
CAS号	90-18-6
分子式	C15H10O8
分子量	318.24
EINECS号	201-973-6
相关类别	植物提取物;对照品;标准品;Flavanols
Mol文件	90-18-6.mol
结构式

六羟黄酮/栎草亭性质

熔点	>300°C
沸点	732.4±60.0 °C(Predicted)
密度	1.912±0.06 g/cm3(Predicted)
储存条件	Store at -20°C
溶解度	DMSO：125 mg/mL（392.79 mM；需要超声波）
形态	结晶固体
酸度系数(pKa)	6.12±0.40(Predicted)
LogP	2.230 (est)

六羟黄酮/栎草亭用途与合成方法

生物活性

Quercetagetin (6-Hydroxyquercetin) 是从 Citrus unshiu (C. unshiu) 果皮中分离的主要类黄酮。Quercetagetin 是一种中等强度和选择性的，细胞渗透性的 pim-1 激酶抑制，IC50 为 0.34 μM。具有抗炎和抗肿瘤活性。

靶点

PIM1

0.34 μM (IC ₅₀ )

PIM2

3.45 μM (IC ₅₀ )

RSK2

2.82 μM (IC ₅₀ )

PKA

21.2 μM (IC ₅₀ )

体外研究

Quercetagetin also inhibits PIM2, PKA, and RSK2 with IC ₅₀ s of 3.45, 21.2, and 2.82 µM, respectively.
Quercetagetin (0.1, 1, 10, and 100 μM, 72 hours) inhibits growth of RWPE2 prostate cancer cells with average ED ₅₀ is 3.8 μM.

Cell Viability Assay

Cell Line:	RWPE2 prostate cancer cells
Concentration:	0.1, 1, 10, and 100 μM
Incubation Time:	72 hours
Result:	Inhibited growth of RWPE2 prostate cancer cells with average ED ₅₀ is 3.8 μM.

体内研究

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively.

Animal Model:	SKH-1 hairless mice model
Dosage:	4 or 20 nmol
Administration:	Topical application; 28 weeks
Result:	Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.

化学性质

来源于万寿菊

安全信息

MSDS信息

六羟黄酮/栎草亭价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/01/25	HY-N4149	Quercetagetin		1 mg	990元
2024/01/25	HY-N4149	六羟黄酮/栎草亭 Quercetagetin	90-18-6	5mg	2100元

六羟黄酮/栎草亭