去水淫羊藿黄素
| 中文名称 | 去水淫羊藿黄素 |
|---|---|
| 中文同义词 | 三七淫羊藿素;淫羊藿素(标准品);ANHYDROICARITIN 脱水淫羊藿素;去水淫羊藿黄素;ANHYDROICARITIN 脱水淫羊藿素 标准品;脱水淫羊藿黄素;去水淫羊藿黄素, >98%;淫羊藿黄素 |
| 英文名称 | Icaritin |
| 英文同义词 | ICARITIN;3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;3,7-bis(2-hydroxyethyl)icaritin;Icaritin, >98%;3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one;Icaritin(Anhydroicaritin);Icaritin>4H-1-Benzopyran-4-one,3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)- |
| CAS号 | 118525-40-9 |
| 分子式 | C21H20O6 |
| 分子量 | 368.38 |
| EINECS号 | |
| 相关类别 | 黄酮类;合成;标准品;植物提取物;对照品;中药对照品;植提标准品;优势产品;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;plant extract;原料药;中间体;原药中间体;对照品-中药对照品;黄酮;标准品 -中药标准品;标准品，对照品;天然高含量单体 |
| Mol文件 | 118525-40-9.mol |
| 结构式 |  |
去水淫羊藿黄素 性质
| 熔点 | 239℃ |
|---|---|
| 沸点 | 582.0±50.0 °C(Predicted) |
| 密度 | 1.359 |
| 闪点 | 206.7℃ |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：可溶5mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 6.44±0.40(Predicted) |
| 颜色 | 淡黄色至深黄色 |
| 最大波长(λmax) | 368nm(MeOH)(lit.) |
| InChI | InChI=1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3 |
| InChIKey | TUUXBSASAQJECY-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(OC)C=C2)OC2=C(C/C=C(/C)\C)C(O)=CC(O)=C2C(=O)C=1O |
Icaritin (4-64 µM; 48 hours; K562, imatinib-resistant cells and primary CML cells) treatment inhibits proliferation of K562, imatinib-resistant cells and primary CML cells .
Icaritin (0-64 µM; 48 hours; K562 and primary cells) treatment induces K562 or primary cells apoptosis in an concentration dependent manner.
Icaritin (32 µM; K562 cells) treatment increases cell population in the sub-G1 phase in K562 cells.
Icaritin (0-64 µM; 48 hours; K562 cells) treatment inhibits MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. Icaritin treatment also significantly inhibits Bcl-2 protein expression and up-regulated Bax protein expression in K562 with a dose-dependent manner accompanied by the cleavage activation of caspase-3 or caspase-9, and a down-regulated expression of Apaf-1.
Cell Proliferation Assay
| Cell Line: | K562, imatinib-resistant cells and primary CML cells |
| Concentration: | 4 µM, 8 µM, 16 µM, 32 µM and 64 µM |
| Incubation Time: | 48 hours |
| Result: | Inhibited cell proliferation. |
Apoptosis Analysis
| Cell Line: | K562 or primary cells |
| Concentration: | 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM |
| Incubation Time: | 48 hours |
| Result: | Induced K562 or primary cells apoptosis. |
Cell Cycle Analysis
| Cell Line: | K562 cells |
| Concentration: | 32 µM |
| Incubation Time: | |
| Result: | Cell population in the sub-G1 phase was increased. |
Western Blot Analysis
| Cell Line: | K562 cells |
| Concentration: | 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM |
| Incubation Time: | 48 hours |
| Result: | Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. |
Icaritin (4-8 mg/kg; intraperitoneal injection; daily; for 10 weeks; female NOD-SCID nude mice) treatment could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow in mouse leukemia model.
| Animal Model: | Female NOD-SCID nude mice (6-8 weeks old) with K562 cells |
| Dosage: | 4 mg/kg and 8 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 10 weeks |
| Result: | Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow. |
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | DJ3100870 |
| 海关编码 | 29329990 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N0678 | Icaritin | 1 mg | 300元 | |
| 2024/01/25 | HY-N0678 | 去水淫羊藿黄素 Icaritin | 118525-40-9 | 5mg | 600元 |