| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
021-33632979 15002134094 |
| Email: |
marketing@targetmol.com |
| Products Intro: |
Product Name:Proadifen
CAS:302-33-0
Package:100 mg;500 mg Remarks: 90+%，具体纯度信息请见官网
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| Company Name: |
QUALITY CONTROL SOLUTIONS LTD.
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| Tel: |
0755-66853366 15920483169 |
| Email: |
sales@chem-strong.com |
| Products Intro: |
Product Name:Proadifen
CAS:302-33-0
Purity:95% HPLC Package:10MG;25MG;50MG;100MG
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| | Proadifen Basic information |
| Product Name: | Proadifen | | Synonyms: | Proadifenum;2,2-Diphenylvaleric acid 2-(diethylamino)ethyl;HL-8727;RP-5171;Acetate, diethylaminoethyldiphenylpropyl;Benzeneacetic acid, alpha-phenyl-alpha-propyl-, 2-(diethylamino)ethyl ester;D011335;Diethylaminoethyldiphenylpropyl acetate | | CAS: | 302-33-0 | | MF: | C23H31NO2 | | MW: | 353.5 | | EINECS: | | | Product Categories: | | | Mol File: | 302-33-0.mol |  |
| | Proadifen Chemical Properties |
| Toxicity | LDLo oral in rat: 500mg/kg |
| | Proadifen Usage And Synthesis |
| Uses | Synergist (non-specific). | | Definition | ChEBI: 2,2-diphenylpentanoic acid 2-(diethylamino)ethyl ester is a diarylmethane. | | Enzyme inhibitor | This nonselective P450 inhibitor (FWfree-base = 353.50 g/mol; CAS 302-33-0;
62-68-0 for the HCl salt), also known as SKF-525A, b-diethylaminoethyl
2,2-diphenylpropylacetate, and N,N-diethylaminoethyl 2,2-
diphenylvalerate, blocks glibenclamide-sensitive K+ channels, including
ATP-sensitive inward rectifier potassium channel 8 (KIR6.1). As a
nonselective inhibitor of cytochrome P450 systems, proadifen also inhibits
drug metabolism, thereby potentiating the action of many pharmaceuticals.
For example, proadifen inhibits the demethylation of 2-methoxyestrogens
. Target (s) : aldehyde oxidase; alkanal monooxygenase, FMN-
linked; aromatase, or CYP19; bacterial luciferase, or alkanal
monooxygenase, FMN-linked; benzoate 4-monooxygenase;
bromomethane monooxygenase7; calcium influx8; ent-copalyl-diphosphate
synthase; CYPC211; cytochrome P450; diamine N-
acetyltransferase; N,N-dimethylaniline demethylase; ecdysone 20-
monooxygenase; ethoxyresorufin O-deethylase; flavin-containing
monooxygenase, or dimethylaniline-N-oxide aldolase; glyceollin
synthase; 2-hydroxyisoflavanone synthase; 25-hydroxyvitamin D3
24-monooxygenase; isopentenyl-diphosphate D-isomerase, or
isopentenyl-pyrophosphate D-isomerase; ent-kaurene synthase;
leukotriene B4 20-hydroxylase; (S) -limonene 3-monooxygenase;
(S) -limonene 6-monooxygenase; (S) -limonene 7-monooxygenase;
methane monooxygenase; monoamine oxidase;
NADPH:cytochrome P450 reductase; nitric-oxide synthase, neuronal
; pentoxyresorufin O-depentylase; phenol O-methyltransferase
; progesterone 11a-monooxygenase; steroid 11b-monooxygenase
; steroid 21-monooxygenase, or CYP21A1, weakly inhibited;
sterol 14-demethylase, or CYP51; styrene monooxygenase; thiol
S-methyltransferase; thromboxane production; and
trimethylamine-oxide aldolase. |
| | Proadifen Preparation Products And Raw materials |
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