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| | curvularin Basic information |
| Product Name: | curvularin | | Synonyms: | curvularin;2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-;S-Curvularin, NSC 166071;(S)-Curvularin | | CAS: | 10140-70-2 | | MF: | C16H20O5 | | MW: | 292.33 | | EINECS: | | | Product Categories: | Antibiotic | | Mol File: | 10140-70-2.mol |  |
| | curvularin Chemical Properties |
| Melting point | 206-206.5° | | alpha | D18 -36.3° (c = 3.8 in ethanol) | | Boiling point | 557.0±29.0 °C(Predicted) | | density | 1.200±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble1mg/mL | | pka | 7.58±0.40(Predicted) | | form | powder | | color | Off-white |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | HS Code | 29419000 |
| | curvularin Usage And Synthesis |
| Uses | Curvularin is a potent antifungal and mycotoxin that also inhibits NO production. | | Uses | Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species, including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology. | | storage | +4°C |
| | curvularin Preparation Products And Raw materials |
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