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Lipoic acid

Lipoic acid Suppliers list
Company Name: Shanghai LanRun Chemical Co., Ltd.  Gold
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Products Intro:CAS:62-46-4
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CAS:62-46-4
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Company Name: Shanghai Boyle Chemical Co., Ltd.  
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Products Intro:Product Name:Lipoic acid
CAS:62-46-4
Company Name: Nanjing Elegant Nutraceuticals Co., Ltd  
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Products Intro:Product Name:Alphalipoic acid
CAS:62-46-4
Purity:HPLC>=99.5% Package:120RMB/ 20mg
Lipoic acid Basic information
B vitamins Uses
Product Name:Lipoic acid
Synonyms:(R)-LIPOIC ACID;6,8-Thioctic acid;6,8-Thiocticacid;6,8-Thiotic acid;6,8-Thioticacid;6-Thioctic acid;6-Thiocticacid;6-Thiotic acid
CAS:62-46-4
MF:C8H14O2S2
MW:206.33
EINECS:200-534-6
Product Categories:PHARMACEUTICALS;FINE Chemical & INTERMEDIATES;chiral;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Pharmaceutical intermediates;Inhibitors;Miscellaneous
Mol File:62-46-4.mol
Lipoic acid Structure
Lipoic acid Chemical Properties
Melting point 48-52 °C(lit.)
Fp >230 °F
CAS DataBase Reference62-46-4(CAS DataBase Reference)
NIST Chemistry ReferenceLipoic acid(62-46-4)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
Lipoic acid Usage And Synthesis
B vitaminsLipoic acid is a class of compounds belonging to the B class vitamins and is the growth factor of yeast and some kinds of microorganisms. It can play the role of coenzyme role in a multi-enzyme system that is responsible for catalyzing the acyl transfer effect in the reaction of oxidative decarboxylation of pyruvate into acetate and oxidative decarboxylation reaction of α-ketoglutarate into succinic acid. Its chemical name is 5-[3-(1,2-dithiol hetero-cycle)] pentanoic acid. The appearance is pale yellow crystals with the molecular weight being 206.33. DL-body: the melting point is 60~61 ℃. L-body (natural products): the melting point is 45~47.5 ℃. Optical rotation [α] D23 + 113 ℃. D-body (natural products): the melting point is 46~48 ℃. Optical rotation [α] D23 + 104 ℃. It is soluble in organic solvents but insoluble in water. It can be used for the prevention and treatment of acute hepatitis, liver cirrhosis, hepatic coma, fatty liver and other diseases. The natural material is found in the liver, kidneys and heart. Synthetic products is obtained through condensation of ethylene and adipic acid mono-ester chloride in the presence of aluminum chloride into chloropropionyl pivaloyl ester, which further has condensation reaction with sulfuric acid, then go through reduction with sodium borohydride and sodium hydroxide hydrolysis, and finally have reaction with thiourea to obtain it.
6,8-lipoic acids can be dissolved in water and can often be presented together with vitamin B1. There are two forms including oxidized and reduced (6,8-dimercapto octanoic acid) types. Inside the body of organisms, some hydrogen group and acyl group can be accepted or transferred through the conversion of these two forms. It can be taken as the coenzyme of the α-keto acid oxidation decarboxylase and hydroxyethyl enzyme and play the role of acyl and hydrogen group transfer during metabolic pathways. Since the human body can synthesize it, no cases of deficiency have been reported before. However, it is indispensable factors for the growth and development of some microorganisms and protozoa. It is rich in liver and yeast.
The above information is edited by the chemicalbook of Dai Xiongfeng.
UsesIt is a kind of B vitamins and can be used for the treatment of acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, diabetes, etc.
It can be used as a kind of antioxidants
Chemical PropertiesThioctic acid, 6,8-dithiooctanoic acid
Useshydrogen-transferring cofactor, potentiating anti-oxidant
DefinitionChEBI: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
Lipoic acid Preparation Products And Raw materials
Raw materialsEthyl 6,8-dichlorooctanoate-->Ethyl 6,8-dichloro caprylate
Tag:Lipoic acid(62-46-4) Related Product Information
(RS)-a-Lipoic Acid-d5,rac a-Lipoic Acid-d5 S-ALPHA-LIPOIC ACID LIPOIC ACID PA RESIN 1,2-Dithiolane-3-valeramide~DL-6,8-Dithiooctanoic acid amide~alpha-Lipoic acid amide,A-LIPOIC ACID AMIDE (R)-Lipoic Acid Nicotinamide Alphla-Lipoic Acid Tromethamine Salt A-LIPOIC ACID,(+/-)-ALPHA-LIPOIC ACID,ALPHA-LIPOIC ACID,DL-A-LIPOIC ACID,LIPOIC ACID, DL-ALPHA- R-Lipoic Acid Potassium Compund ACETIC ACID ASCORBICACID Folic acid Lipoic acid Hyaluronic acid Citric acid Isovaleric acid DL-ALPHA-LIPOIC ACID REDUCED FORM,DL-ALPHA-LIPOIC ACID, DIHYDRO-,LIPOIC ACID, REDUCED,alpha-Lipoic acid, dihydro-,Lipoic acid, dihydro-,Reduced lipoic acid,DL-a-Lipoic Acid, Dihydro- dithiolane DL-α-Lipoic acid,LIPOIC ACID, DL-ALPHA-,DL-ALPHA-LIPOIC ACID,DL-A-LIPOIC ACID,ALPHA-LIPOIC ACID,(+/-)-ALPHA-LIPOIC ACID,Alpha Lipoic Acid ( or DL-Thioctic Acid ),A-LIPOIC ACID