单硫酸胍乙啶
| 中文名称 | 单硫酸胍乙啶 |
|---|---|
| 中文同义词 | 硫酸胍乙啶(单硫酸胍乙啶、胍乙啶单硫酸盐);单硫酸胍乙啶 100MG;单硫酸胍乙啶;硫酸胍乙啶;GUANETHI二NE 单磺酸盐;胍乙啶单硫酸盐;硫酸胍乙啶[645-43-2];单硫酸呱乙啶 |
| 英文名称 | GUANETHIDINE SULFATE |
| 英文同义词 | GUANETHIDINE MONOSULFATE;GUANETHIDINE MONOSULFATE (1:1);GUANETHIDINE SULFATE;(2-(hexahydro-1(2h)-azocinyl)ethyl)guanidinehydrogensulfate;(2-(hexahydro-1(2h)-azocinyl)ethyl)-guanidinsulfate(1:1);2-(octahydro-1-azocinyl)ethylguanidinesulphate;n-(2-guanidinoethyl)heptamethyleniminesulfate;Guanethidine Sulphae |
| CAS号 | 645-43-2 |
| 分子式 | C10H24N4O4S |
| 分子量 | 296.39 |
| EINECS号 | 211-442-0 |
| 相关类别 | 医药原料;小分子抑制剂;小分子抑制剂，天然产物;试剂;原料中间体-原料药;特色原料;兽药原料药;标准品;Inhibitors |
| Mol文件 | 645-43-2.mol |
| 结构式 |  |
单硫酸胍乙啶 性质
| 熔点 | 276-281 °C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 易溶于水，几乎不溶于乙醇（96%） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
| InChIKey | YUFWAVFNITUSHI-UHFFFAOYSA-N |
| CAS 数据库 | 645-43-2(CAS DataBase Reference) |
Guanethidine sulfate (Guanethidine monosulfate) 是一种抗高血压药。Guanethidine sulfate 也是一种肾上腺素能神经元阻滞药，通过神经元胺载体进入去甲肾上腺素能神经末梢。
Guanethidine (5-40 mg/kg; intraperitoneal injection; daily; for 4-28 days; male Wistar rats) treatment for 28 days by 40 mg/kg results in an incomplete sympathectomy accompanied by a partially irreversible hypersensitivity to noradrenaline, whereas 5 mg/kg does not induce histological or permanent haemodynamic changes.
| Animal Model: | Male Wistar rats (approximately 200 g) |
| Dosage: | 5 mg/kg or 40 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 4, 8, 14, or 28 days |
| Result: | Lowered the blood pressure by 40 mg/kg, the decrease being reversible on discontinuation. The hypersensitivity was partly reversible on discontinuation, but a significantly increased sensitivity of the heart rate to noradrenaline was observed 60 days after discontinuation by 40 mg/kg for 28 days. Histologically a profound loss of nerve cells of the superior cervical ganglion was observed by 40 mg/kg. |
用途
为肾上腺.素能神经阻断剂。其作用是干扰交感神经末梢去甲肾上腺.素的释放，亦耗竭去甲肾上腺.素的贮存，因而当肾上腺.素能神经冲动达到末梢时，不再有足量的介质进行传递，交感神经活动降低，血压下降，其降压作用较强而持久。主要用于中度和重度舒张压高的高血压、较顽固的高血压及肾性高血压等。