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| | (R)-(+)-1-(1-Naphthyl)ethylamine Basic information |
| | (R)-(+)-1-(1-Naphthyl)ethylamine Chemical Properties |
| Melting point | 135-136 °C | | Boiling point | 153 °C11 mm Hg(lit.) | | alpha | 60 º (c=2, CH3OH) | | density | 1.067 g/mL at 20 °C(lit.) | | refractive index | n20/D 1.623(lit.) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) | | form | Liquid | | pka | 9.26±0.40(Predicted) | | Specific Gravity | 1.07 | | color | brown | | optical activity | [α]20/D +55°, c = 2 in ethanol | | Water Solubility | Soluble in water (<10/l). | | Sensitive | Air Sensitive | | BRN | 2208025 | | Stability: | Stable. Air-sensitive. Incompatible with acids, oxidizing agents, acid anhydrides, chloroformates, acid chlorides. | | InChIKey | RTCUCQWIICFPOD-SECBINFHSA-N | | CAS DataBase Reference | 3886-70-2(CAS DataBase Reference) | | EPA Substance Registry System | 1-Naphthalenemethanamine, .alpha.-methyl-, (.alpha.R)- (3886-70-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | 2735 | | WGK Germany | 3 | | RTECS | QJ6963000 | | F | 10-34 | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29211990 |
| | (R)-(+)-1-(1-Naphthyl)ethylamine Usage And Synthesis |
| Description | (R)-(+)-1-(1-Naphthyl)ethylamine is a reagent used in the formation of isolated acids via salt formation. It is also a raw material for the synthesis of (R)-1-(1-Naphthyl)ethyl isocyanate. In materials research, the use of Reflectance Absorption Infrared Spectroscopy (RAIRS) can be used to study the structure, bonding and orientation of R-1- nea and (S)-(-)-1-(2-naphthyl)ethylamine (S-2- nea) on Pd(1 1 1). | | Chemical Properties | Colorless to light yellow liqui | | Uses | It is used in chiral synthesis in organic reactions including the synthesis of β-amino acids and the enantioselective of ketones to nitroolefins. Also used as absolute configuration of primary amines determined using chiral (2-nitrophenyl)proline amides and H NMR. | | Uses | (R)-(+)-1-(1-Naphthyl)ethylamine is used in chiral synthesis in organic reactions including the synthesis of β-amino acids and the enantioselective of ketones to nitroolefins. | | Application | Absolute configuration of primary amines determined using chiral (2-nitrophenyl)proline amides and 1H NMR. | | General Description | (R)-(+)-1-(1-Naphthyl)ethylamine is a chiral derivatization reagent useful for all gas chromatography (GC) applications in the chiral field. It is specially selected to meet the requirements for derivatization reagents for enantiomeric excess determinations. | | Solubility in organics | (R)-(+)-1-(1-Naphthyl)ethylamine is soluble in chloroform and ethanol. Insoluble in water. | | Purification Methods | Purify the amine by distillation in a good vacuum. [Mori et al. Tetrahedron 37 1343 1981, cf Wilson in Topics Stereochem (Allinger and Eliel eds) v o l 6 135 1971, Fredga et al. Acta Chem Scand 11 1609 1957.] The hydrochlorides crystallise from H2O [] D 18 ±3.9o (c 3, H2O), and the sulfates recrystallise from H2O as tetrahydrates m 230-232o. The RS-amine has b 153o/11mm, 156o/15mm, 183.5o/41mm [Blicke & Maxwell J Am Chem Soc 6 1 1780 1939]. [Beilstein 12 III 3111.] |
| | (R)-(+)-1-(1-Naphthyl)ethylamine Preparation Products And Raw materials |
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