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Pranlukast

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Products Intro: Product Name:Pranlukast
CAS:103177-37-3
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro:Product Name:Pranlukast
CAS:103177-37-3
Purity:99% Package:1Kg; 5Kg; 10Kg; 25Kg; 100Kg
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Products Intro:Product Name:Pranlukast
CAS:103177-37-3
Package:100Mg,1g
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Products Intro:Product Name:ONO 1078;N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzaMide
CAS:103177-37-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Products Intro:Product Name:Pranlukast
CAS:103177-37-3
Remarks:C14821
Pranlukast Basic information
Asthma drugs
Product Name:Pranlukast
Synonyms:PRANLUKAST;4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh;benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox;emihydrate;ONO-RS-411;ONO-RS-411-01;N-[4-keto-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide;N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide
CAS:103177-37-3
MF:C27H23N5O4
MW:481.5
EINECS:201-616-4
Product Categories:Aromatics;Heterocycles;API;Antiasthmatic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:103177-37-3.mol
Pranlukast Structure
Pranlukast Chemical Properties
Melting point 236-238°C
storage temp. Store at +4°C
CAS DataBase Reference103177-37-3(CAS DataBase Reference)
Safety Information
Hazard Codes F,C
Risk Statements 11-34
Safety Statements 16-26-36/37/39-45
MSDS Information
Pranlukast Usage And Synthesis
Asthma drugsPranlukast is a common respiratory drug, it belongs to asthma drugs , it is the cysteinyl leukotrienes (LTs) receptor antagonist and it can bind to LTC4, LTD4, LTE4 receptors selectively to antagonize their effect . Roles and application are similar to zafirlukast. It is clinically used for the prevention of bronchial asthma. Oral 225mg once, 2 times one day, morning and evening after meal. After taking ,there may be gastrointestinal reactions,or there may be nausea, vomiting, abdominal pain, diarrhea or constipation, sometimes , fever, rash, pruritus and liver function abnormalities such as serum aminotransferase or bilirubin increase are visible . Pregnant women should use with caution , the elderly should take appropriate reductions. This product can not alleviate the onset of asthma.
At present, three leukotriene receptor antagonists are used for the following purposes:
1, zafirlukast :it is effective for mild to moderate asthma ,it can cause improvement in dose-dependent lung function, and reduce the amount of β agonists. Absorption of the product is affected by food, it should not be taken together with food. Oral each 20mg, 2 times/d.
2, montelukast: it is valid for intermittent or persistent asthma in adults and children. This product is approved by the FDA for the treatment of children aged 6 to 12. Absorption of the product is not affected by food, it can be taken with food . Oral each 10mg, once/d.
3, pranlukast :it is used for mild to moderate asthma, pranlukast can increase patients maximum expiratory flow,and improve asthma symptoms, it can be used as a daily treatment of chronic asthma. Each oral 450mg, 2 times/d.
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesOff-white solid
UsesA potent, selective and orally active CysLT receptor antagonist. Leukotriene antagonist. Used as an antiasthmatic
Usesantiasthmatic;leukotriene receptor-1 antagonist
UsesLabeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry.
Biological ActivitySelective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4-7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.
Pranlukast Preparation Products And Raw materials
Tag:Pranlukast(103177-37-3) Related Product Information
Zafirlukast Montelukast sodium Butoxybenzene Pranlukast 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 4-ETHOXY-N-PHENYLBENZAMIDE 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE 3-Amino-2-hydroxyacetophenone 4-ethoxy-N-(2-methoxyphenyl)benzamide 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE