山楂酸
中文名称 | 山楂酸 |
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中文同义词 | 山楂酸;山楂叶提取物山楂叶黄酮;山楂酸, 来源于山楂;2Α-羟基齐墩果酸、马斯里酸;山楂酸(2Α-羟基齐墩果酸、马斯里酸);山楂酸,马斯里酸(标准品);MASLINIC ACID 山楂酸;山楂酸MASLINIC ACID |
英文名称 | Maslinic acid |
英文同义词 | MASLINIC ACID, 98%;(4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid;CRATEGOLIC ACID (PLEASE CALL);(2alpha,3beta)-2,3-Dihydroxy-olean-12-en-28-oic acid;CRATEGOLIC ACID(MASLINIC ACID)(P);Maslinic Acid(Crategolic Acid);Maslinic acid, Crataegolic acid;Crategolic acid, froM Crataegus pinnatifida |
CAS号 | 4373-41-5 |
分子式 | C30H48O4 |
分子量 | 472.7 |
EINECS号 | |
相关类别 | 五环三萜;中药对照品;标准品;植物提取物;对照品;医药中间体;Pentacyclic Triterpenes;Miscellaneous;高纯植物提取物;标准品-对照品;对照品-中药对照品;三萜;标准品 -中药标准品;标准品,对照品;医药、农药及染料中间体;Natural Products;天然产物;化学试剂 |
Mol文件 | 4373-41-5.mol |
结构式 |
山楂酸 性质
熔点 | 267~269℃ |
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沸点 | 570.0±50.0 °C(Predicted) |
密度 | 1.14±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 丙酮:可溶1mg/mL,澄清,无色 |
酸度系数(pKa) | 4.63±0.70(Predicted) |
形态 | 粉末 |
颜色 | 白色至类白色 |
稳定性 | 吸湿性 |
InChIKey | MDZKJHQSJHYOHJ-LLICELPBSA-N |
SMILES | [C@@]12(C)CC[C@@]3([H])C(C)(C)[C@@H](O)[C@H](O)C[C@]3(C)[C@@]1([H])CC=C1[C@]3([H])CC(CC[C@]3(C(=O)O)CC[C@@]21C)(C)C |&1:0,4,9,11,14,16,21,27,33,r| |
LogP | 7.870 (est) |
西班牙格拉纳达大学的科学家发现山楂酸能够抑制丝氨酸蛋白酶,而艾滋病病毒正是利用这种酶将自身从被感染的细胞中向外部释放,扩散至病毒感染者全身。
山楂酸具有抗肿瘤、抗艾滋病病毒作用,能使艾滋病病毒在体内扩散的几率降低80%。本品应在低温干燥保存,特殊产品要在氮气下保存,长时间保存不当含量会有所降低。Maslinic acid 可抑制 NF-κB p65 的 DNA 结合活性, 并消除 IκB-α 磷酸化。
Target | Value |
NF-κB
() |
Maslinic acid (MA) inhibits LPS-induced NF-κB translocation to nucleus and phosphorylation of IκB-α. Maslinic acid has also been reported to suppress NF-κB regulated osteoclastogenesis in bone marrow monocytes and inhibit TNF-α-induced NF-κB activity and its downstream genes’ expression in pancreatic cancer cells. To confirm if the anti-inflammatory effects of olive pomace extracts (OPEs) inRAW264.7 cells can be attributed to Maslinic acid, dose-dependence experiments determined the effective concentration of Maslinic acid to be 10-20 μM. 20 μM Maslinic acid significantly suppresses TNF-α production and inhibits IL-1, IL-6, and COX-2 mRNA expression in RAW 264.7 cell. Maslinic acid (at 10 and 20 μM) significantly suppresses the DNA-binding activity of NF-κB p65 in LPS-induced RAW 264.7 cells. Pretreatment with Maslinic acid significantly reduces the LPS-induced phosphorylation of IκB-α.
Paw swelling is alleviated when mice are administered with 200 mg/kg Maslinic acid (MA), significantly suppressing inflammation, compared to the carrageenan induced control group, 4 h after λ-carrageenan injection (0.91±0.51 mm and 1.79±0.4 mm, respectively).
药理药效:抗肿瘤、抗艾滋病病毒、抗炎、抗菌等作用
安全信息
安全说明 | 24/25 |
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WGK Germany | 3 |
海关编码 | 29181990 |
毒害物质数据 | 4373-41-5(Hazardous Substances Data) |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/16 | S9040 | 山楂酸 Maslinic acid | 4373-41-5 | 1mg | 794.48元 |