对羟基苯乙烯
| 中文名称 | 对羟基苯乙烯 |
|---|---|
| 中文同义词 | 4-乙烯基苯酚 1G;4-乙烯基苯酚, 10% 丙二醇溶液;4-羟基苯乙烯;4-乙烯基苯酚;4-乙烯基苯酚, MIN 10% 丙二醇溶液;4-乙烯基苯酚, 大约为10%丙二醇溶液;4-乙烯苯酚;4-乙烯基苯酚, 大约为丙二醇溶液 |
| 英文名称 | 4-Hydroxystyrene |
| 英文同义词 | 4-Vinylphenol solution 10 wt. % in propylene glycol;4-Vinylphenol,10%soln.inpropyleneglycol;PARA-VINYLPHENOL;4-Vinylphenol in 10% sol. Propylene glycol;4-VINYLPHENOL (10% SOLUTION IN PROPYLENE GLYCOL);4-VINYL PHENOL 10% IN PROPYLENE GLYCOL;p-Oxystyrene;Styrene-4-ol |
| CAS号 | 2628-17-3 |
| 分子式 | C8H8O |
| 分子量 | 120.15 |
| EINECS号 | 220-103-6 |
| 相关类别 | 合成材料中间体;香精香料;化工原料;其他原料;化工;对羟基苯乙烯;光刻胶单体;Aromatic Phenols |
| Mol文件 | 2628-17-3.mol |
| 结构式 |  |
对羟基苯乙烯 性质
| 熔点 | 73 °C |
|---|---|
| 沸点 | 228.85°C (estimate) |
| 密度 | 1.04 |
| 蒸气压 | 9.38hPa at 25℃ |
| 折射率 | 1.4440 |
| FEMA | 3739 | P-VINYLPHENOL |
| 闪点 | >230 °F |
| 储存条件 | under inert gas (nitrogen or Argon) at 2-8°C |
| 溶解度 | 可溶于氯仿（少量）、DMSO（少量） |
| 形态 | 液体 |
| 酸度系数(pKa) | 9.95±0.26(Predicted) |
| 颜色 | 透明无色至橙色 |
| 气味 (Odor) | 0.01% 的丙二醇溶液。化学酚类味道 |
| 香型 | phenolic |
| 水溶解性 | Slightly miscible with water. |
| 敏感性 | Hygroscopic |
| JECFA Number | 711 |
| BRN | 506844 |
| 稳定性 | 感光 |
| LogP | 2.3 at 25℃ |
| CAS 数据库 | 2628-17-3(CAS DataBase Reference) |
| NIST化学物质信息 | 4-hydroxystyrene(2628-17-3) |
| EPA化学物质信息 | Phenol, 4-ethenyl- (2628-17-3) |
GRAS(FEMA)。FEMA(mg/kg)：焙烤制品、肉制品、调味汁，5.0；冷饮、甜沙司，2.5；凝胶、布丁、甜点、糖霜、果仁制品、硬糖，2.0；无醇饮料1.5；含醇饮料0.5；代乳品3.0；胶姆糖10.0。4-Vinylphenol 存在于药用草白花蛇舌草，野生稻中，也是葡萄酒中乳酸菌对对香豆酸和阿魏酸的代谢产物。4-Vinylphenol 诱导凋亡 (apoptosis)，在体内抑制血管形成并抑制浸润性乳腺肿瘤生长。
4-Vinylphenol (12.5-200 µg/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 µg/mL.
4-Vinylphenol (0.15 or 0.3 µg/mL; 3 days) reduces sphere‑formation and vimentin expression on CSCs in breast cancer.
4-Vinylphenol (50, 100 µg/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells.
4-Vinylphenol (100 µg/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis.