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GW9662

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
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Products Intro: Product Name:GW9662
CAS:22978-25-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: Biochempartner
Tel: 0086-13720134139
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Products Intro: Product Name:GW9662
CAS:22978-25-2
Purity:98% HPLC LCMS Package:10G;20G
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
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Products Intro: Product Name:GW9662
CAS:22978-25-2
Purity:0.99 Package:5KG;1KG
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Products Intro: Product Name:GW9662
CAS:22978-25-2
Purity:98% Package:1KG;3USD
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-87569265 +86-18612256290
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Products Intro: Product Name:GW9662
CAS:22978-25-2
Purity:99% Package:5mg;USD|100mg;USD|10g;USD|500g;USD|25KG;USD

GW9662 manufacturers

  • GW9662
  • GW9662 pictures
  • $0.00 / 5mg
  • 2021-07-20
  • CAS:22978-25-2
  • Min. Order: 5mg
  • Purity: 99%
  • Supply Ability: 2000tons
  • GW9662
  • GW9662 pictures
  • $3.00 / 1KG
  • 2020-02-01
  • CAS:22978-25-2
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 100KG
GW9662 Basic information
Product Name:GW9662
Synonyms:GW9662, >=98%;2-CHLORO-5-NITROBENZANILIDE;GW9662;TIMTEC-BB SBB006523;2-Chloro-5-nitro-N-4-phenylbenzamide;BenzaMide,2-chloro-5-nitro-N-phenyl-;N-[(2-chloro-5-nitrophenyl)-phenylmethylidene]hydroxylamine;2-Chloro-5-nitrobenzanilide 97%
CAS:22978-25-2
MF:C13H9ClN2O3
MW:276.68
EINECS:636-590-7
Product Categories:Inhibitor;Intracellular receptor;Inhibitors;Amides;Carbonyl Compounds;Organic Building Blocks
Mol File:22978-25-2.mol
GW9662 Structure
GW9662 Chemical Properties
Melting point 158-159 °C (lit.)
Boiling point 360.9±32.0 °C(Predicted)
density 1.440±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 26 mg/mL, soluble
form solid
pka11.77±0.70(Predicted)
color white
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKeyDNTSIBUQMRRYIU-UHFFFAOYSA-N
CAS DataBase Reference22978-25-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36-43
Safety Statements 26-36/37-24/25-22
WGK Germany 3
HS Code 29242990
MSDS Information
ProviderLanguage
SigmaAldrich English
GW9662 Usage And Synthesis
DescriptionGW-9662 (22978-25-2) is a selective PPARγ antagonist (IC50 = 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively).1 Blocks the inhibition of osteoclast formation induced by IL-4 (1-2 μM).2 Displays anticancer activity inhibits growth of human mammary tumor cell lines.3 GW-9662 is a useful tool for dissecting the involvement of PPARγ in cellular physiology.4,5
Chemical PropertiesOff-White Solid
UsesA cell-permeable, selective and irreversible PPAR antagonist (IC50 = 3.3 nM, 32 nM, and 2 for PPAR, PPARa, and PPARd, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 , also
UsesGW9662 has been used as a peroxisome proliferator activated receptor γ (PPARγ) antagonist in human pluripotent stem cells, in phenylephrine stimulated cardiomyocytes and to inhibit the protective effect of telmisartan pheochromocytoma, PC12 cells.
UsesAn irreversible PPAR antagonist
DefinitionChEBI: GW 9662 is a member of benzamides.
Biological ActivitySelective PPAR γ antagonist (IC 50 values are 3.3, 32 and 2000 nM for PPAR γ , PPAR α and PPAR δ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μ M), therefore is more potent than BADGE (2,2-Bis[4-(2,3-epoxypropoxy)phenyl]propane ). Anticancer, inhibits growth of human mammary tumor cell lines.
Biochem/physiol ActionsGW9662 (2-chloro-5-nitrobenzanilide) binds to the ligand binding site of the peroxisome proliferator activated receptor γ (PPARγ) and results in the inhibition of adipocyte differentiation. It favors cell growth suppression in breast cancer cell lines even in the presence of PPARγ agonist rosiglitazone. It stimulates M2c macrophages differentiation and triggers growth arrest-specific 6 (Gas6) expression. GW9662 co treatment with other PPARγ ligands elicits antiproliferative effects on the glioblastoma stem cells and could be a potent therapeutic agent.
storageStore at RT
References1) Leesnitzer et al. (2002), Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662; Biochemistry, 41 6640 2) Bendixen et al. (2001), IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1; Proc. Natl. Acad. Sci. USA, 98 2443 3) Seargent et al. (2004), GW9662, a potent antagonist of PPARgamma inhibits growth of breast cancer tumour cells and promotes the anticancer effects of the PPARgamma agonist rosiglitazone, independently of PPARgamma activation; Br. J. Pharmacol., 143 933 4) Cheng et al. (2014), β-Caryophyllene Ameliorates the Alzheimer-Like Phenotype in APP/PS1 Mice through CB2 Receptor Activation and the PPARγ Pathway; Pharmacology, 94 1 5) Liu et al. (2014), Curcumin protects neurons against oxygen-glucose deprivation/reoxygenation-induced injury through activation of peroxisome proliferator-activated-γ function; J. Neuro. Sci. Res., 92 1549
GW9662 Preparation Products And Raw materials
Tag:GW9662(22978-25-2) Related Product Information
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