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| | EQUILENIN Basic information |
| Product Name: | EQUILENIN | | Synonyms: | 3-hydroxyoestra-1,3,5(10),6,8-pentaen-17-one;(+)-EQUILENIN;EQUILENIN;D-1,3,5(10),6,8-ESTRAPENTAEN-3-OL-17-ONE;D-EQUILENIN;1,3,5(10)-6,8-ESTRAPENTAEN-3-OL-17-ONE;3-HYDROXYESTRA-1,3,5,7,9-PENTAEN-17-ONE;3-HYDROXY-1,3,5(10),6,8-ESTRAPENTAEN-17-ONE | | CAS: | 517-09-9 | | MF: | C18H18O2 | | MW: | 266.33 | | EINECS: | 208-230-5 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Miscellaneous Natural Products | | Mol File: | 517-09-9.mol |  |
| | EQUILENIN Chemical Properties |
| Melting point | 258-259° | | alpha | D16 +87° (12.8 mg made up to 1.8 ml in dioxane) | | Boiling point | 349.54°C (rough estimate) | | density | 1.1305 (rough estimate) | | refractive index | 1.4800 (estimate) | | Fp | 2 °C | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | pka | pKa 9.72 (H2O t=25.0±0.02 ) (Uncertain);9.75±0.06 (Uncertain) | | form | Solid | | color | Pale Yellow to Light Beige | | Water Solubility | 1.52mg/L(25 ºC) | | EPA Substance Registry System | Equilenin (517-09-9) |
| | EQUILENIN Usage And Synthesis |
| Uses | Equilenin is a naturally occuring estrogenic steroidal hormone (1,2) isolated from urine of pregnant mares (3). Not found in human urine. Component of conjugated estrogenic hormones. Estrogen. This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. | | Uses | Estrogenic steroidal hormone isolated from urine of pregnant mares. Occurs naturally in the d-form. Not found in human urine. Component of conjugated estrogenic hormones. Estrogen. | | Definition | ChEBI: Equilenin is a 3-hydroxy steroid that is estrone which carries two double bonds at positions 6 and 8. It is found in the urine of pregnant mare's and extensively used for estrogen replacement therapy in postmenopausal women. It has a role as a mammalian metabolite and an antioxidant. It is a 3-hydroxy steroid and a 17-oxo steroid. | | Purification Methods | Crystallise (+)-equilenin from EtOH (solubility is 0.63% at 18o, 2.5% at 78o), aqueous EtOH or *C6H6 (Norite) and dry it in a vacuum. It sublimes on melting and at 170-180o/0.01mm. The acetate crystallises from MeOH with m 165-167o and [ ] D +71o (c 1, CHCl3). [Bachmann et al. J Am Chem Soc 62 824 1940, Beilstein 8 III 1522, 1523, 1525, 8 IV 1420.] |
| | EQUILENIN Preparation Products And Raw materials |
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