Centhaquine
| 中文名称 | Centhaquine |
|---|---|
| 中文同义词 | 化合物CENTHAQUINE |
| 英文名称 | Centhaquine |
| 英文同义词 | Centhaquine;2-[2-[4-(3-Methylphenyl)-1-piperazinyl]ethyl]quinoline;Centhaquin;Centhaquin PMZ-2010;PMZ-2010;Quinoline, 2-[2-[4-(3-methylphenyl)-1-piperazinyl]ethyl]-;Centhaquin >=98% (HPLC);Centhaquin (Centhaquine,PMZ-2010) |
| CAS号 | 57961-90-7 |
| 分子式 | C22H25N3 |
| 分子量 | 331.45 |
| EINECS号 | |
| 相关类别 | 医药原料;贝尔卡主打 |
| Mol文件 | 57961-90-7.mol |
| 结构式 |  |
Centhaquine 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 二甲基亚砜：62.5 mg/mL（188.57 mM） |
Centhaquine (Centhaquin) 是一种具有研究出血性休克的潜力的试剂。Centhaquine 在出血模型中可以减少全身血管阻力。
Centhaquine (Centhaquin) (intravenous injection, 0.01-1.0 mg/kg; intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner. Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci. Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of catecholamines, improving both the macro- and microcirculation during CPR.
| Animal Model: | Landrace/Large White piglets |
| Dosage: | 0.015mg/kg |
| Administration: | Intravenous administration; Adrenaline 0.02mg/kg plus Centhaquin 0.015mg/kg |
| Result: | Added to adrenaline improved ROSC rates in a swine model of VF cardiac arrest. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-106690 | Centhaquine Centhaquin | 57961-90-7 | 5mg | 700元 |
| 2024/01/25 | HY-106690 | Centhaquine Centhaquin | 57961-90-7 | 10mM * 1mLin DMSO | 770元 |