7-羟基-4-胆甾烯-3-酮
| 中文名称 | 7-羟基-4-胆甾烯-3-酮 |
|---|---|
| 中文同义词 | 7-羟基-4-胆甾烯-3-酮;7Α-羟基- 4 -胆固醇-3 -酮;7-羟基-4-胆甾烯-3-酮 标准品;7Α-羟基-4-胆固醇-3-酮;化合物 T10196;7A-羟基-4-胆甾烯-3-酮;7Α-羟基胆甾烯酮;7Α-羟基-4-胆甾烯-3-酮 |
| 英文名称 | (7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one |
| 英文同义词 | 7a-Hydroxy-cholestene-3-one;7 alpha-hydroxy-4-cholesten-3-one;(7a)-7-Hydroxycholest-4-en-3-one;7a-Hydroxy-4-cholesten-3-one;7a-Hydroxycholest-4-en-3-one;(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one;(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-diMethyl-17-((R)-6-Methylheptan-2-yl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one;7HCO |
| CAS号 | 3862-25-7 |
| 分子式 | C27H44O2 |
| 分子量 | 400.64 |
| EINECS号 | |
| 相关类别 | 脂类;Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids |
| Mol文件 | 3862-25-7.mol |
| 结构式 |  |
7-羟基-4-胆甾烯-3-酮 性质
| 熔点 | 182-184°C |
|---|---|
| 沸点 | 516.7±29.0 °C(Predicted) |
| 密度 | 1.03±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.49±0.70(Predicted) |
| 颜色 | 白色至类白色 |
Endogenous Metabolite
Pregnane X receptor (PXR)
7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids (e.g. chenodeoxycholic acid). The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by 3β-hydroxy steroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one.
7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-113259 | 7-羟基-4-胆甾烯-3-酮 7α-Hydroxy-4-cholesten-3-one | 3862-25-7 | 1mg | 3500元 |