CHLOROPROCAINE

CHLOROPROCAINE Suppliers list
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:CHLOROPROCAINE
CAS:133-16-4
Purity:99% Package:1KG;1.8USD
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739
Email: info@dycnchem.com
Products Intro: Product Name:Chloroprocaine
CAS:133-16-4
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Wholesale price
Company Name: Shaanxi Didu New Materials Co. Ltd
Tel: +86-89586680 +86-13289823923
Email: 1026@dideu.com
Products Intro: Product Name:chloroprocaine;133-16-4
CAS:133-16-4
Purity:0.99 Package:25KG,200L
Company Name: PT CHEM GROUP LIMITED
Tel: +86-85511178 +86-85511178
Email: peter68@ptchemgroup.com
Products Intro: Product Name:Chloroprocaine
CAS:133-16-4
Purity:0.95&0.99 Package:0.1KG;1KG;1000KG Remarks:Wholesale price
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490
Email: info@gihichemicals.com
Products Intro: Product Name:Chloroprocaine
CAS:133-16-4
Purity:99 Package:5KG;1KG,25kg
CHLOROPROCAINE Basic information
Product Name:CHLOROPROCAINE
Synonyms:CHLOROPROCAINE;2-DIETHYLAMINOETHYL 4-AMINO-2-CHLORO-BENZOATE;2-Chloroprocaine;4-amino-2-chloro-benzoicaci2-(diethylamino)ethylester;Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester;Chloroprocain;Chlorprocaine;Halestyn
CAS:133-16-4
MF:C13H19ClN2O2
MW:270.76
EINECS:
Product Categories:
Mol File:133-16-4.mol
CHLOROPROCAINE Structure
CHLOROPROCAINE Chemical Properties
Melting point 42°C
Boiling point 402.6±35.0 °C(Predicted)
density 1.2020 (rough estimate)
refractive index 1.5270 (estimate)
pka9.14±0.25(Predicted)
Safety Information
Hazardous Substances Data133-16-4(Hazardous Substances Data)
MSDS Information
CHLOROPROCAINE Usage And Synthesis
DescriptionChloroprocaine (N,N′-diethylaminoethyl 4-amino-2-chlorobenzoate) is a very short-acting, amino ester-type local anesthetic used to provide regional anesthesia by infiltration as well as by peripheral and central nerve block, including lumbar and caudal epidural blocks. The presence of a chlorine atom ortho to the carbonyl of the ester function increases its rate of hydrolysis by plasma cholinesterase at least threefold compared to procaine and benzocaine. Thus, chloroprocaine may be used in maternal and neonatal patients with minimal placental passage of chloroprocaine. The lower plasma cholinesterase activity in the maternal epidural space must still have sufficient activity for degrading chloroprocaine and, thus, not allowing it to cross the placenta barrier. Like PABA, the hydrolysis product of chloroprocaine, 4-amino-2-chlorobenzoic acid, also inhibits the action of sulfonamides. Therefore, its use with sulfonamides should be avoided.
UsesAnesthetic (local).
UsesChloroprocaine is an ester that is metabolised rapidly by ester hydrolysis, so its duration of action is short and potential for cardiac toxicity relatively low. It can be used as a preservative-free solution for spinal anaesthesia for surgical procedures up to 40 min in duration.
DefinitionChEBI: Procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of const icting blood vessels, so reducing bleeding.
Brand nameNesacaine (Abraxis).
Biological FunctionsChloroprocaine hydrochloride (Nesacaine) is obtained from addition of a chlorine atom to procaine, which results in a compound of greater potency and less toxicity than procaine itself. This local anesthetic is hydrolyzed very rapidly by cholinesterase and therefore has a short plasma half-life. Because it is broken down rapidly, chloroprocaine is commonly used in obstetrics. It is believed that the small amount that might get to the fetus continues to be rapidly hydrolyzed, so there may be no residual effects on the neonate.
General DescriptionThe 2 chloride substitution on the aromatic ring of chloroprocaineis an electron-withdrawing functional group. Thus, itpulls the electron density from the carbonyl carbon into thering. The carbonyl carbon is now a stronger electrophile andmore susceptible to ester hydrolysis. Therefore, chloroprocainehas a more rapid metabolism than procaine. The in vitroplasma half-life is approximately 25 seconds. The 2-chloro-4-aminobenzoic acid metabolite precludes this from being usedin patients allergic to PABA. The very short duration of actionmeans that this drug can be used in large doses for conductionblock (with rapid onset and short duration of action.).
Clinical UseChloroprocaine is used for cutaneous or mucous membraneinfiltration for surgical procedures, epidural anesthesia(without preservatives) and for peripheral conduction block.
CHLOROPROCAINE Preparation Products And Raw materials
Tag:CHLOROPROCAINE(133-16-4) Related Product Information
2-(Dimethylamino)ethyl benzoate Benzocaine hydrochloride 4-Amino-2-chlorobenzoic acid Ethanolamine benzoate hydrochloride, 98+% CHLOROPROCAINE Chloroprocaine hydrochloride Ethyl 2-Chlorobenzoate Procaine hydrochloride 4-AMINOBENZOIC ACID HCL 2-DIETHYLAMINOETHANOL HYDROCHLORIDE Methyl 2-chlorobenzoate Methyl 4-amino-2-chlorobenzoate 2-(BENZYLOXY)-1-ETHANAMINE HYDROCHLORIDE 2-Chlorobenzoic acid METHYL 4-AMINOBENZOATE HYDROCHLORIDE 3-Chloro-4-methylaniline hydrochloride 4-Amino-2-chlorobenzoic acid ethyl ester p-Toluidine, alpha-(2-(diethylamino)ethoxy)-