ChemicalBook > Product Catalog >API >Hormones and the Endocrine System >Adrenocorticotropic hormone drugs >Triamcinolone acetonide

Triamcinolone acetonide

Triamcinolone acetonide Suppliers list
Company Name:Nanjing Sunlida Biological Technology Co., Ltd.  Gold
Tel:025-58378339 18913321387
Email:sales@sunlidabio.com
Company Name:WuHan YuanCheng Gongchuang Technology Co.Ltd  Gold
Tel:027-50756250/076/168/190/126/190
Email:gy08@yccreate.com
Company Name:Shanghai CanSpecsci Instrument Co., Ltd.  Gold
Tel:400 608 7598
Email:order@canspecsci.com
Company Name:Hubei Prosperity Galaxy Chemical CO,.Ltd.  Gold
Tel:027-83557761 13396052830
Email:1498703467@qq.com
Company Name:Jiangxi Guifeng Technology Co., Ltd.  Gold
Tel:0791-86565026 15797847505
Email:gfkjjx@qq.com
Triamcinolone acetonide Basic information
Appearance and properties Glucocorticoid drugs Application Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Triamcinolone acetonide
Synonyms:KENALOG;ARISTODERM;9ALPHA-FLUORO-11BETA,21-DIHYDROXY-16ALPHA,17-ISOPROPYLIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE;9ALPHA-FLUORO-16ALPHA-HYDROXYPREDNISOLONE 16ALPHA,17ALPHA-ACETONIDE;9ALPHA-FLUORO-11BETA,16ALPHA,17ALPHA,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE 16,17-ACETONIDE;9a-fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide;9a-fluoro-16a-hydroxyprednisolone 16a,17a-acetonide;ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRA-HYDROXYPREGNA-1,4-DIENE-3,20-DIONE
CAS:76-25-5
MF:C24H31FO6
MW:434.5
EINECS:200-948-7
Product Categories:Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;NASACORT
Mol File:76-25-5.mol
Triamcinolone acetonide Structure
Triamcinolone acetonide Chemical Properties
mp 274-278°C (dec.)
storage temp. Refrigerator
Merck 9596
Stability:Combustible. Incompatible with strong oxidizing agents.
NIST Chemistry ReferenceTriamcinolone acetonide(76-25-5)
EPA Substance Registry SystemPregna-1,4-diene- 3,20-dione, 9-fluoro-11,21-dihydroxy-16, 17-[(1-methylethylidene)bis( oxy)]-, (11.beta.,16.alpha.)-(76-25-5)
Safety Information
Hazard Codes T
Risk Statements 61
Safety Statements 53-45
WGK Germany 3
RTECS TU3920000
Triamcinolone acetonide Usage And Synthesis
Appearance and propertiesTriamcinolone acetonide, its acetate form appears to be white or white-like crystalline powder. The drug is odorless, with bitter taste. It is hardly soluble in water, slightly soluble in ethanol, soluble in chloroform, and slightly soluble in acetone.
Glucocorticoid drugsTriamcinolone acetonide is a kind of long-term glucocorticoid drugs which is now widely used in clinical Dermatology of China. It belongs to adrenocorticotropic hormone drugs. It is the derivative of Triamcinolone, and with the same function as Triamcinolone. Triamcinolone acetonide functions in anti-inflammatory, anti-allergic, anti-itching and shrinking capillaries. What’s more, besides its weak water-sodium retention, the effect of Triamcinolone acetonide for anti-inflammatory, anti-allergic is much stronger and more durable than hydrocortisone (10 to 30 folds), and prednisone. It can also treat bronchial asthma by aerosol inhalation with very strong and durable effect. Triamcinolone acetonide has better efficacy on local treatment compared with triamcinolone. It is Oral absorbed easily. Taking orally 5mg of the drug yields a bioavailability of about 23%. Its plasma concentration reaches peak (105 ng/mL) within one hour with the half-life is being 2 hours; It has a slow intramuscular absorption rate which takes effect within hours, and gives maximal effect within 1 to 2 days. The effect can be maintained for 2 ~ 3 weeks; the absorption rate of intradermal and intra-articular injection of the drug is low, but has a long-lasting effect; generally the efficacy can be maintained for more than 1-2 week per injection. This product has a low binding rate with plasma albumin protein, and is metabolized into non-active product in the liver, kidneys and tissues which is then further excreted by the kidneys. It also has a long-lasting effect upon local injection. Moreover, topical ointments can also produce a good effect. Clinically triamcinolone acetonide is used for treatment of various skin diseases such as atopic dermatitis, contact dermatitis, seborrheic dermatitis, neurodermatitis, eczema, psoriasis, psoriasis, lichen planus and skin pruritus, as well as bronchial asthma, rheumatoid arthritis, acute sprains, chronic ache in back and legs, frozen shoulder, tenosynovitis, ophthalmic inflammation, oral mucosal congestion, erosion, ulcers, granulomatous cheilitis, and oral mucosa chronic infectious diseases, Furthermore, it can also be used for local injection treatment in keloid, cystic acne, discoid lupus erythematosus, alopecia areata and other small area of damages. Triamcinolone acetonide nasal spray can be used for the prevention and treatment of perennial, seasonal allergic rhinitis, and vasomotor rhinitis. Intra-articular injection of this drug can eliminate inflammation and pain, swelling or can alleviate, pain, stiffness and swelling feeling.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
ApplicationIt is adrenal cortex hormones drugs used for treating diseases such as neurodermatitis, eczema, psoriasis, joint pain, and asthma.
CategoryToxic Substances.
Toxicity gradingHighly toxic.
Acute toxicitySubcutaneous - rat LD50: 13.1 mg / kg; intraperitoneal - Mouse LD50: 105 mg / kg.
Flammability hazard characteristicsCombustible; combustion produces toxic fumes of fluoride.
Storage CharacteristicsTreasury: ventilation, low-temperature and dry; store separately from food raw materials.
Extinguishing agentDry powder, foam, sand, carbon dioxide, water spray.
Chemical PropertiesWhite Solid
UsageA glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).
Usageantiinflammatory
Triamcinolone acetonide Preparation Products And Raw materials
Tag:Triamcinolone acetonide(76-25-5) Related Product Information
FLUOCINONIDE, [3H]- Triamcinolone acetonide 21-(benzoyl-b-aminoisobutyrate),Triamcinolone acetonide benzoyl-b-aminoisobutyrate Triamcinolone hexacetonide triamcinolone furetonide TRIAMCINOLONE ACETONIDE, [3H]- AMCINONIDE amcinafal flumoxonide Fluocinolone acetonide Triamcinolone acetonide fluoro jade 1-Hydroxyethylidene-1,1-diphosphonic acid Hydroxyethyl Cellulose Hydroxy silicone oil Triamcinolone acetonide 21-acetate Ethyl maltol Hydroxyethyl starch Triamcinolone