血根碱

血根碱

中文名称血根碱
中文同义词血根碱硫酸盐;氯化血根碱(标准品);氯化血根碱/盐酸血根碱;血根碱水合物;盐酸血根碱, 来源于博落回;盐酸血根碱(氯化血根碱);2 - 氨基-9 - [4 - 羟基-3 - (羟甲基)丁基]-3H-嘌呤-6 - 酮;氯化血根碱
英文名称SANGUINARINE CHLORIDE
英文同义词SANGUINARINE CHLORIDE;SANGUINARINE HCL;PSEUDOCHELERYTHRINE;PSEUDOCHELERYTHRINE CHLORIDE;13-METHYL-[1,3]BENZODIOXOLO[5,6-C]-1,3-DIOXOLO[4,5-I] PHENANTHRIDINIUM CHLORIDE;Sanguinarine chloride, froM Macleaya cordata;[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium,13-methyl-, chloride (1:1);3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(chlo
CAS号5578-73-4
分子式C20H14ClNO4
分子量367.78
EINECS号
相关类别分析标准品;标准品;植物提取物;植物生化提取物;中药标准品;生物碱;植提标准品;;小分子抑制剂;小分子抑制剂,天然产物;医药原料;植提;其他生化试剂;分析对照品;分析试剂标准品;标准品-对照品;对照品-中药对照品;对照品;Alkaloids;AlkaloidCancer Research;Anti-proliferative AgentsVoltage-gated Ion Channels;Ion Pump Inhibitors;Biochemicals Found in Plants;Chemopreventive Agents;Monovalent Ion Channels;Nutrition Research;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;VIADENT;Inhibitors;标准品 -中药标准品;分析试剂-标准品;中药对照品
Mol文件5578-73-4.mol
结构式血根碱 结构式

血根碱 性质

熔点281-285°C
储存条件Inert atmosphere,2-8°C
溶解度甲醇:20 mg/mL,澄清,橙色
形态橙色固体
颜色橙色至深橙色
稳定性有吸湿性、光敏性

血根碱 用途与合成方法

Sanguinarine (Sanguinarin) chloride 是一种来源于 Sanguinaria Canadensis 的生物碱,可通过激活活性氧 (ROS) 的产生来刺激细胞凋亡。Sanguinarine 诱导的细胞凋亡与 JNK 和 NF-κB 的活化有关。
TargetValue
PP2C
(Cell-free)
0.68 μM(Ki)

Sanguinarine (SANG)-induced apoptosis is associated with the activation of JNK and NF-κB signal pathways.To determine the effects of Sanguinarine on cell viability, 22B-cFluc cells are stimulated with different concentrations of Sanguinarine for 24 h, and then a CKK-8 assay is performed. The treatment with Sanguinarine decreases the proliferation of 22B cells in a dose-dependent manner. Meanwhile, the cytosolic extracts of 22B-cFluc cells treated with different dose of Sanguinarine are measured to detect cellular caspase-3 activity using Ac-DEVD-pNA, which is a validated caspase-3 substrate. The absorbance at 450 nm increases in a dose-dependent manner, indicating increased caspase-3 activity stimulated by Sanguinarine.

To evaluate the apoptosis induced by Sanguinarine (SANG) in vivo, 22B-cFluc cells are inoculated subcutaneously into one flank of nude mice and xenograft models are allowed to establish. Mice are treated intravenously with 10 mg/kg of Sanguinarine. At 24, 48 and 72 h after treatment, bioluminescent imaging is performed after i.p. injection of mice with 150 mg/kg of D-luciferin substrate. Sanguinarine treatment induces an obvious increase of luminescent signal as early as 48 h after initial treatment. A sustained bioluminescent imaging (BLI) intensity increased is observed throughout the course of experiment. At 72 h after treatment, the tumors are collected and subjected to TUNEL staining for evaluating apoptosis. Compared with the control tumors, the group treated with Sanguinarine exhibits significantly more cell apoptosis, indicated by the increased green signals from the sporadic apoptotic cells.

化学性质 
红色针状结晶,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于博落回。
用途 
一个具有抗菌,消炎,抗氧化性能的天然产物。有抑制肿瘤细胞株扩增和促凋亡作用。

安全信息

危险品标志Xn
危险类别码22
安全说明36-26
WGK Germany3
RTECS号VP5220000
F10
海关编码29399990

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-N0052ASanguinarine chloride1 mg365元
2024/01/25HY-N0052A血根碱
Sanguinarine chloride
5578-73-45mg800元

血根碱 上下游产品信息

下游产品
"血根碱"相关产品信息
盐酸血根碱 乙氧基血根碱 枸橼酸血根碱 二氢血根碱 血根碱 硝酸血根碱 1-甲基氯化吡啶 7-羟基异喹啉 2-萘甲醚 盐酸喹啉 2,3-二羟基萘 8-羟基异喹啉 血根碱 7-甲氧基异喹啉 8-甲氧基异喹啉 7,8-苯并喹啉 异喹啉 菲啶
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