血根碱
中文名称 | 血根碱 |
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中文同义词 | 血根碱硫酸盐;氯化血根碱(标准品);氯化血根碱/盐酸血根碱;血根碱水合物;盐酸血根碱, 来源于博落回;盐酸血根碱(氯化血根碱);2 - 氨基-9 - [4 - 羟基-3 - (羟甲基)丁基]-3H-嘌呤-6 - 酮;氯化血根碱 |
英文名称 | SANGUINARINE CHLORIDE |
英文同义词 | SANGUINARINE CHLORIDE;SANGUINARINE HCL;PSEUDOCHELERYTHRINE;PSEUDOCHELERYTHRINE CHLORIDE;13-METHYL-[1,3]BENZODIOXOLO[5,6-C]-1,3-DIOXOLO[4,5-I] PHENANTHRIDINIUM CHLORIDE;Sanguinarine chloride, froM Macleaya cordata;[1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium,13-methyl-, chloride (1:1);3)benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium,13-methyl-(chlo |
CAS号 | 5578-73-4 |
分子式 | C20H14ClNO4 |
分子量 | 367.78 |
EINECS号 | |
相关类别 | 分析标准品;标准品;植物提取物;植物生化提取物;中药标准品;生物碱;植提标准品;碱;小分子抑制剂;小分子抑制剂,天然产物;医药原料;植提;其他生化试剂;分析对照品;分析试剂标准品;标准品-对照品;对照品-中药对照品;对照品;Alkaloids;AlkaloidCancer Research;Anti-proliferative AgentsVoltage-gated Ion Channels;Ion Pump Inhibitors;Biochemicals Found in Plants;Chemopreventive Agents;Monovalent Ion Channels;Nutrition Research;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;VIADENT;Inhibitors;标准品 -中药标准品;分析试剂-标准品;中药对照品 |
Mol文件 | 5578-73-4.mol |
结构式 |
血根碱 性质
熔点 | 281-285°C |
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储存条件 | Inert atmosphere,2-8°C |
溶解度 | 甲醇:20 mg/mL,澄清,橙色 |
形态 | 橙色固体 |
颜色 | 橙色至深橙色 |
稳定性 | 有吸湿性、光敏性 |
Target | Value |
PP2C
(Cell-free) | 0.68 μM(Ki) |
Sanguinarine (SANG)-induced apoptosis is associated with the activation of JNK and NF-κB signal pathways.To determine the effects of Sanguinarine on cell viability, 22B-cFluc cells are stimulated with different concentrations of Sanguinarine for 24 h, and then a CKK-8 assay is performed. The treatment with Sanguinarine decreases the proliferation of 22B cells in a dose-dependent manner. Meanwhile, the cytosolic extracts of 22B-cFluc cells treated with different dose of Sanguinarine are measured to detect cellular caspase-3 activity using Ac-DEVD-pNA, which is a validated caspase-3 substrate. The absorbance at 450 nm increases in a dose-dependent manner, indicating increased caspase-3 activity stimulated by Sanguinarine.
To evaluate the apoptosis induced by Sanguinarine (SANG) in vivo, 22B-cFluc cells are inoculated subcutaneously into one flank of nude mice and xenograft models are allowed to establish. Mice are treated intravenously with 10 mg/kg of Sanguinarine. At 24, 48 and 72 h after treatment, bioluminescent imaging is performed after i.p. injection of mice with 150 mg/kg of D-luciferin substrate. Sanguinarine treatment induces an obvious increase of luminescent signal as early as 48 h after initial treatment. A sustained bioluminescent imaging (BLI) intensity increased is observed throughout the course of experiment. At 72 h after treatment, the tumors are collected and subjected to TUNEL staining for evaluating apoptosis. Compared with the control tumors, the group treated with Sanguinarine exhibits significantly more cell apoptosis, indicated by the increased green signals from the sporadic apoptotic cells.
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-N0052A | Sanguinarine chloride | 1 mg | 365元 | |
2024/01/25 | HY-N0052A | 血根碱 Sanguinarine chloride | 5578-73-4 | 5mg | 800元 |