化合物 T16947
| 中文名称 | 化合物 T16947 |
|---|---|
| 中文同义词 | 化合物 T16947;化合物SU16F;SU 16F,PDGFRΒ抑制剂 |
| 英文名称 | SU 16f |
| 英文同义词 | 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl- |
| CAS号 | 251356-45-3 |
| 分子式 | C24H22N2O3 |
| 分子量 | 386.44 |
| EINECS号 | |
| 相关类别 | Angiogenesis and Metastasis |
| Mol文件 | 251356-45-3.mol |
| 结构式 |  |
化合物 T16947 性质
| 沸点 | 661.7±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.292±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | 在 DMSO 中溶解度为 100 mM |
| 形态 | 暗橙色固体 |
| 酸度系数(pKa) | 4?+-.0.10(Predicted) |
|
PDGFRβ 10 nM (IC 50 ) |
PDGFR2 140 nM (IC 50 ) |
PDGFR1 2.29 μM (IC 50 ) |
SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM .
Cell Proliferation Assay
| Cell Line: | SGC-7901 cells in GC-MSC/SGC-7901 co-culture system |
| Concentration: | 20 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. |
Western Blot Analysis
| Cell Line: | SGC-7901 cells |
| Concentration: | 20 μM |
| Incubation Time: | 8 hours |
| Result: | Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-108628 | 化合物 T16947 SU16f | 251356-45-3 | 1 mg | 480元 |
| 2024/04/30 | HY-108628 | 化合物 T16947 SU16f | 251356-45-3 | 5mg | 980元 |