NF449
| 中文名称 | NF449 |
|---|---|
| 中文同义词 | |
| 英文名称 | NF449 |
| 英文同义词 | NF449 Sodium Salt;NF449 octasodium |
| CAS号 | 627034-85-9 |
| 分子式 | C41H32N6O29S8 |
| 分子量 | 1329.23558 |
| EINECS号 | |
| 相关类别 | Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds |
| Mol文件 | 627034-85-9.mol |
| 结构式 |  |
NF449 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于H2O |
| 形态 | 结晶固体 |
| 水溶解性 | Soluble to 50 mM in water with gentle warming |
| 稳定性 | 吸湿性 |
NF449 suppressed the rate of GTP[γS] binding to rG sα-s while barely affecting binding to rG iα-1 (IC 50 =140 nM), inhibits stimulation of adenylyl cyclase activity in S49 cyc− membranes (deficient in endogenous Gsα) by exogenously added Gsα-s, and blocks the coupling of β-adrenergic receptors to G s (EC 50 =7.9 μM).
At a dose of 10 mg/kg, NF449 inhibits the ex vivo aggregation triggered by 5 g/ml collagen in WT mouse platelets without affecting that induced by 5 μM ADP. At a higher dose (50 mg/kg), NF449 inhibits ex vivo platelet aggregation in response to not only 10 g/ml collagen but also 5 M ADP, indicating nonselective inhibition of the P2Y1 and/or P2Y12 receptor.