IKK2抑制剂（LY2409881）
| 中文名称 | IKK2抑制剂（LY2409881） |
|---|---|
| 中文同义词 | 2-[5-氯-2-[[3-(4-甲基-1-哌嗪基)丙基]氨基]-4-嘧啶基]-N-环丙基-苯并[B]噻吩-4-甲酰胺三盐酸盐;IKK2抑制剂(LY2409881);LY2409881三盐酸盐;化合物LY2409881 TRIHYDROCHLORIDE;2-(5-氯-2-((3-(4-甲基哌嗪-1-基)丙基)氨基)嘧啶-4-基)-N-环丙基苯并[B]噻吩-4-羧酰胺 三盐酸盐 |
| 英文名称 | LY2409881 trihydrochloride |
| 英文同义词 | LY2409881 trihydrochloride;2-(5-chloro-2-(3-(4-methylpiperazin-1-yl)propylamino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride;2-[5-Chloro-2-[[3-(4-methyl-1-piperazinyl)propyl]amino]-4-pyrimidinyl]-N-cyclopropylbenzo[b]thiophene-4-carboxamide trihydrochloride;LY2409881 triHCl;LY2409881 trihydrochloride USP/EP/BP;2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide;2-{5-chloro-2-[3-(4-methylpiperazin-1-yl)-propylamino]-pyrimidin-4-yl}-benzo[b]thiophene-4-carboxylic acid cyclopropylamide tri-hydrochloride;LY-2409881 ;LY 2409881 |
| CAS号 | 946518-60-1 |
| 分子式 | C24H30Cl2N6OS |
| 分子量 | 521.51 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;Inhibitors |
| Mol文件 | 946518-60-1.mol |
| 结构式 |  |
IKK2抑制剂（LY2409881） 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 超声波检测下 DMSO 中≥59.4 mg/mL；不溶于乙醇；不溶于水 |
| 形态 | 固体 |
LY2409881 是一种有效的选择性 IKK2 抑制剂，IC50 为 30 nM，选择性比IKK1和其他常见激酶高10倍多。LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-B0788A | IKK2抑制剂（LY2409881） LY2409881 trihydrochloride | 946518-60-1 | 2mg | 800元 |
| 2024/01/25 | HY-B0788A | IKK2抑制剂（LY2409881） LY2409881 trihydrochloride | 946518-60-1 | 5mg | 1200元 |