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Dimenhydrinate

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Products Intro:Product Name:DiMenhydrinate
CAS:523-87-5
Package:500Mg,5g
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Products Intro:Product Name:Dimenhydrinate
CAS:523-87-5
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Products Intro:Product Name:Dimenhydrinate
CAS:523-87-5
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Products Intro:Product Name:N-(2-DiphenylMethoxyethyl)-N,N-DiMethylaMMoniuM 8-Chlorotheophyllinate
CAS:523-87-5
Purity:99% Package:5KG;1KG
Company Name: Chemsky(shanghai)International Co.,Ltd.  
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Products Intro:Product Name:DiMenhydrinate
CAS:523-87-5
Purity:98%
Dimenhydrinate Basic information
Anti-motion sickness Traits Effect Medicine interactions Precautions Adverse reactions Uses
Product Name:Dimenhydrinate
Synonyms:THEOHYDRAMINE;N-[2-DIPHENYLMETHOXYETHYL]-N,N-DIMETHYLAMMONIUM 8-CHLORO-THEOPHYLLINATE;DRAMAMINE;DIMENHYDRINATE;2-(benzhydryloxy)-n,n-dimethylethylamine 8-chlorotheophyllinate;8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione compound with 2-(diphenylmethoxy)-n,n-dimethylethanamine (1:1);2-(benzhydryloxy)-n,n-dimethylethylaminecompd.with8-chlorotheophylline;2-(diphenylmethoxy)-n,n-dimethylethylamine8-chlorotheophyllinate
CAS:523-87-5
MF:C17H21NO.C7H7ClN4O2
MW:469.97
EINECS:208-350-8
Product Categories:Amines;Aromatics;Drug Analogues;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;DRAMAMINE
Mol File:523-87-5.mol
Dimenhydrinate Structure
Dimenhydrinate Chemical Properties
Melting point 102-107°C
solubility Soluble in ethanol
Water Solubility Slightly soluble (0.1-1 g/100 mL at 22 ºC)
CAS DataBase Reference523-87-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-61-36/37/38
Safety Statements 22-26-36/37/39-53
WGK Germany 3
RTECS XH5082000
TSCA Yes
Hazardous Substances Data523-87-5(Hazardous Substances Data)
Dimenhydrinate Usage And Synthesis
Anti-motion sicknessDimenhydrinate is a complex salt of diphenhydramine and 8-chloro-theophylline. Antihistamine effect is weaker than diphenhydramine , and its anti-motion sickness and antiemetic effects are stronger. Mainly it is used to prevent and control nausea, vomiting, dizziness and Meniere's syndrome caused by motion sickness, .It is effective to treat a variety of dizziness, vomiting caused by radiation therapy, pregnancy, surgery, inner ear infections, and the use of drugs (such as streptomycin) .
TraitsDimenhydrinate is transparent white crystalline powder, odorless, slightly soluble in water, soluble in ethanol.
EffectAs a complex salt of diphenhydramine and 8-chloro-theophylline,its role is the same as diphenhydramine hydrochloride, but its anti-histamine effect is weaker than the latter. It can inhibit medulla vomiting chemosensory area and it has a general central pivot inhibition effect and anticholinergic effects, which makes it have sedative and antiemetic effects.
It is quickly and completely absorbed after oral administration, it is effective after 15 to 60 minutes , the role is sustainable after 3-6 hours, the elimination phase half-life (t1/2β) is 4~6 hours, plasma protein binding rate is high. Mainly it is metabolized in the liver, it is excreted in urine in the form of metabolites . Patients with hepatic insufficiency using this service,because it can accumulate in the body , the dose should be reduced.
The above information is edited by the chemicalbook of Tian Ye.
Medicine interactions 1.It can not be taken with other CNS depressants and it cannot be taken after drinking.
2. It can be used to make ethanol, central nervous system depressants, tricyclic antidepressants more effective. It can momentarily affect barbiturates and sulfacetamide sodium absorption; if it is used with sodium aminosalicylate , plasma concentration of the latter is decreased.
3. Administration with food or milk can reduce the irritation of the stomach of the drug .
Precautions 1. The composition of the production and other ethanolamine allergies, newborns and premature infants are disabled.
2. It pregnant women in early pregnancy within four months use the drug, the incidence of congenital cardiovascular abnormalities and inguinal hernia of the fetus may be increased, the relationship with drug use has not been confirmed. Early pregnancy should not take this product.
3. The anti-emetic effect of the product can adds difficulty in diagnosing appendicitis and drug-induced reactions.
4. Lethargy , inability to concentrate etc.,can occur after treatment, ,patients should not drive cars, boats, etc., and it is not suitable to engage in the highly difficult and dangerous machine operation.
Adverse reactions Low toxicity, high doses can cause drowsiness, and even cause a rash. Long-term use may cause blood diseases.
UsesIt is suitable for motion-sickness, pregnancy, radiation therapy , surgery etc. induced nausea , vomiting and dizziness.
Chemical PropertiesWhite Solid
UsesUsed for treating vertigo, motion sickness, and nausea associated with pregnancy
UsesAn antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).
DefinitionChEBI: The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention nd treatment of motion sickness.
General DescriptionCrystalline white powder.
Air & Water ReactionsSlightly soluble in water. Slightly acidic.
Health HazardSYMPTOMS: Symptoms associated with Dimenhydrinate include: drowsiness, lethargy, fatigue hypnosis and coma. Initial sedation may be followed by central nervous system hyperexcitability. Also, the victim may experience dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, and/or diarrhea.
Fire HazardFlash point data for Dimenhydrinate are not available but Dimenhydrinate is probably non-flammable.
Dimenhydrinate Preparation Products And Raw materials
Tag:Dimenhydrinate(523-87-5) Related Product Information
8-CHLOROXANTHINE Diphenhydramine 2-CHLORO-5-METHYL-1H-IMIDAZOLE 2-(DIPHENYLMETHOXY)-N-METHYLETHYLAMINE 4-Amino-5-imidazolecarboxamide hydrochloride 2-Chloro-1H-imidazole Theophylline monohydrate Dimenhydrinate Dimethyl fumarate Chlorodiphenylphosphine tert-Butylchlorodiphenylsilane Dimethyl sulfoxide Dimethyl ether 4-Methoxyphenylacetone 2,6-Dimethyl-7-octen-2-ol 4-Methoxybenzylchloride Anisole 3-Methoxybenzaldehyde