去铁铵

去铁铵

中文名称去铁铵
中文同义词甲磺酸去铁胺;甲磺酸去铁敏;甲磺酸除铁灵;去铁铵/去铁敏;DEFEROX胺甲磺酸盐;去铁铵;去铁胺甲磺酸酯;去铁胺甲磺酸盐
英文名称DEFEROXAMINE MESYLATE
英文同义词deferoxaminemesilate;deferoxaminemethanesulfonate;desferalmesylate;desferalmethanesulfonate;desferrioxaminebmesylate;Deferoxamine Mesylate (300 mg);N-[5-[3-[(5-aMinopentyl)hydroxycarbaMoyl]propionaMido]pentyl]-3-[[5-(N-hydroxyacetaMido);N1-(5-aMinopentyl)-N1-hydroxy-N4-[5-[[4-[[5-(acetylhydroxyaMino)pentyl]aMino]-1,4-dioxobutyl]hydroxyaMino]pentyl]butanediaMide Methanesulfonate
CAS号138-14-7
分子式C26H52N6O11S
分子量656.79
EINECS号205-314-3
相关类别医药中间体;小分子抑制剂;小分子抑制剂,天然产物;医药原料药-科研原料;医药原料;试剂盒-细胞分析试剂盒;Aliphatics;Amines;Chelating Agents & Ligands;Intermediates & Fine Chemicals;Pharmaceuticals;DESFERAL;Inhibitors;标准品
Mol文件138-14-7.mol
结构式去铁铵 结构式

去铁铵 性质

熔点148-149°
储存条件2-8°C
溶解度H2O:50 mg/mL
形态粉末
颜色白色至类白色
水溶解性Soluble to 100 mM in water

去铁铵 用途与合成方法

Deferoxamine mesylate (Desferrioxamine B, DFOM)是Deferoxamine的甲磺酸盐,它可形成铁络合物并用作螯合剂。Deferoxamine 是一种铁死亡的抑制剂,可在体外低氧和高血糖状态下稳定 HIF-1α 的表达并改善HIF-1α的活性。Deferoxamine 可降低 beta-amyloid (Aβ) 的沉积并诱导自噬。
TargetValue
HIF-1α
()
Beta Amyloid
()
Ferroptosis
()

Deferoxamine treatment significantly increases HIF-1α binding under all culture conditions, including hypoxic and high-glucose. The mechanism of deferoxamine is through improving HIF-1α biological function through scavenging oxygen free radicals. Deferoxamine (5 μM) has significant effect on the tumor-associated stromal cells cellular multiplication, and cells die at day 7 after exposure to 50 μM and 100 μM deferoxamine. Deferoxamine (5 μM-100 μM) inhibits the proliferation of BMMSCs, and induces apoptosis of MSCs in a dose-dependent manner. Deferoxamine influences the expression of adhesion proteins on MSCs. Deferoxamine (30, 60, 120 μM) shows lower expression of HIF-1α in a concentration dependent way in AdMSCs.

Deferoxamine (100 mg/kg, i.p.) lowers the mortality rate of subarachnoid hemorrhage (SAH) rat. Deferoxamine (100 mg/kg, i.p.) attenuates Evan’s blue extravasation in cortex, ameliorates the tight junction detachment and preserves the integrity of the base membrane examined in electron microscope at day 3 after SAH. Deferoxamine attenuates degradation of BBB proteins after SAH and significantly reduces ferritin expression at day 3 in the cortex, and improves neurologic behavior and cognitive deficits after experimental. Ten µL of 1 mM deferoxamine-treated wounds display significantly accelerated healing from day 7 onward and heal significantly faster than control-treated wounds in diabetic mice. Deferoxamine-treated wounds and dimethyloxalylglycine-treated wounds heal significantly faster than control-treated wounds in aged mice. In deferoxamine (10 mg/mL)-treated TG mice, there is a decrease in both soluble and insoluble Aβ40 and Aβ42. Both pGSK3β and β-catenin are significantly increased by approximately 50% in the deferoxamine-treated mice.

安全信息

安全说明22-24/25
WGK Germany2
RTECS号UG5310000
海关编码29280000
毒性man,TDLo,parenteral,16gm/kg/34W-I (16000mg/kg),CARDIAC: PERICARDITISGASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINEBLOOD: OTHER CHANGES,American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-B0988Deferoxamine mesylate20 mg200元
2024/01/25HY-B0988去铁铵
Deferoxamine mesylate
138-14-7100mg500元

去铁铵 上下游产品信息

"去铁铵"相关产品信息
羟基脲 草酸高铁铵 去铁铵 去铁胺 氯化铁铵 十二水合硫酸铁铵 乙二胺四乙酸铁铵 硫酸高铁铵标液 硫酸亚铁铵六水合物 六(氰基-C)高铁酸铁(3+)铵盐(4-)(1:1:1) 柠檬酸铁铵,棕色 硫酸铁铵 草酸高铁铵 田安 柠檬酸铁铵 田安水溶液
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