乙氧苯噻唑胺
中文名称 | 乙氧苯噻唑胺 |
---|---|
中文同义词 | 依索唑胺;乙氧苯噻唑胺 |
英文名称 | 6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE |
英文同义词 | 6-ETHOXYZOLAMIDE;6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE;ETHOXZOLAMIDE;2-Benzothiazolesulfonamide, 6-ethoxy-;6-Ethoxy-1,3-benzothiazole-2-sulfonamide;6-ethoxy-2-benzothiazolesulfonamid;6-Ethoxybenzothiazole-2-sulfonamide;Cardrase |
CAS号 | 452-35-7 |
分子式 | C9H10N2O3S2 |
分子量 | 258.32 |
EINECS号 | 207-199-5 |
相关类别 | ANTIZOL |
Mol文件 | 452-35-7.mol |
结构式 |
乙氧苯噻唑胺 性质
熔点 | 190-193 °C(lit.) |
---|---|
沸点 | 464.9±37.0 °C(Predicted) |
密度 | 1.4767 (rough estimate) |
折射率 | 1.6800 (estimate) |
储存条件 | Refrigerator |
溶解度 | 可溶于DMSO(少许)、乙酸乙酯(少许) |
酸度系数(pKa) | pKa 8.12(H2O t=25.0) (Uncertain) |
形态 | 固体 |
颜色 | 米白色 |
水溶解性 | 10.33mg/L(25 ºC) |
Merck | 13,3790 |
Ki: 1 nM (carbonic anhydrase)
Ethoxzolamide (ETZ) treatment causes >90% inhibition of reporter GFP fluorescence in infected macrophages. Moreover, in a 9-day macrophage survival assay, Ethoxzolamide (ETZ) treatment significantly inhibits the ability of M. tuberculosis to grow intracellularly.
It is discovered that the lipid-soluble ethoxzolamide is converted in vivo to a water-soluble metabolite, while retaining high activity againstt the enzyme. At the minimal dose for maximal effect (4 mg/kg i.v. at 45 min) the IOP lowering is 4.2 mmHg, the concentration in anterior uvea is 2.5 pmol/kg, and the fractional inhibition of the enzyme (i) is 0.9995. The effect declines rapidly, attributable to the very short half-life of drug in plasma, leading to depletion of free drug in the anterior uvea and other tissues. Ethoxzolamide (ETZ) strongly downregulates GFP reporter fluorescence in mouse lungs, with 3-fold inhibition of GFP signal compare to that in the mock-treating control. There is a significant reduction of bacterial survival in the lungs of ETZ-treating mice compare to the mock-treating control.
安全信息
危险品标志 | Xi |
---|---|
危险类别码 | 36/37/38 |
安全说明 | 26 |
WGK Germany | 3 |
RTECS号 | DL6390000 |
毒害物质数据 | 452-35-7(Hazardous Substances Data) |
提供商 | 语言 |
---|---|
英文
|