阿罗洛尔
| 中文名称 | 阿罗洛尔 |
|---|---|
| 中文同义词 | 阿罗洛尔;阿罗洛尔溶液,100PPM;阿罗洛尔溶液,1000PPM;5-(2-((3-(叔丁胺基)-2-羟丙基)硫基)噻唑-4-基)噻吩-2-甲酰胺;化合物 T10371 |
| 英文名称 | AROTINOLOL |
| 英文同义词 | AROTINOLOL;Arottnolol;2-(3-tert-Butylamino-2-hydroxypropylthio)-4-(5-carbamoyl-2-thienyl)thiazole;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-;2-Thiophenecarboxamide, 5-[2-[[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-, (+-)-;NSC 317940;5-[2-[[3-(tert-butylamino)-2-hydroxy-propyl]thio]thiazol-4-yl]thiophene-2-carboxamide;5-[2-[3-(tert-butylamino)-2-hydroxy-propyl]sulfanyl-1,3-thiazol-4-yl]thiophene-2-carboxamide |
| CAS号 | 68377-92-4 |
| 分子式 | C15H21N3O2S3 |
| 分子量 | 371.54 |
| EINECS号 | |
| 相关类别 | 医药原料药;降糖降压产品 |
| Mol文件 | 68377-92-4.mol |
| 结构式 |  |
阿罗洛尔 性质
| 熔点 | 148-149° |
|---|---|
| 沸点 | 599.8±60.0 °C(Predicted) |
| 密度 | 1.35 |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 酸度系数(pKa) | 13.71±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 灰白色至浅黄色 |
|
5-HT 2A Receptor
|
Arotinolol shows its selectivity of β-adrenergic receptors, the result of Arotinolol for β1 and β2 adrenoceptors in 125 I-ICYP binding to rat cerebral cortical membranes with pK i value of 9.74 and 9.26 respectively. The selectively of β1 and β2 is equal. Arotinolol shows its potency for inhibiting the binding of the same radioligand to 5HT1B-serotonergic receptor site, Arotinolol displaces 125 I-ICYP binding to 5HT1B-receptors with the pK i values of 7.97 and 8.16 resepectively for β1 and β2 adrenergic receptors.
Arotinolol (oral gavage; 200 mg/kg; 8 weeks) can significantly decrease central arterial pressure (CAP) and pulse wave velocity (PWV), in addition, it reduces aortic collagen depositions and finally improves arterial stiffness in SHR mouse.
| Animal Model: | SHR mice |
| Dosage: | 200 mg/kg |
| Administration: | Orally gavage; 200 mg/kg; once daily; 8 weeks |
| Result: | Improved arterial stiffness in SHR. |
安全信息
阿罗洛尔 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-122537A | 阿罗洛尔 Arotinolol | 68377-92-4 | 10mM * 1mLin DMSO | 740元 |
| 2024/01/25 | HY-122537A | 阿罗洛尔 Arotinolol | 68377-92-4 | 5mg | 900元 |