雄甾-1,4,6-三烯-3,17-二酮
| 中文名称 | 雄甾-1,4,6-三烯-3,17-二酮 |
|---|---|
| 中文同义词 | 雄甾-1,4,6-三烯-3,17-二酮;ATD (1,4,6三烯-雄甾-3,17-二酮);化合物 T10321;1.4.6-雄甾三烯-3.17-二酮 |
| 英文名称 | ANDROSTA-1,4,6-TRIENE-3,17-DIONE |
| 英文同义词 | androsta-1,4,6-triene-3,17-dione;Δ1,4,6-androgen;1,4,6-Andorstatriene-3,17-dione;Androsta-1,4,6-triene-3,17-dione (1.0mg/mL in MeOH);1,4,6-Androstatriene-3,17-dione(ATD);ANDROSTA-1,4,6-TRIENE-3,17-DIONE(ATD);6-triene-3;Androsta-1 |
| CAS号 | 633-35-2 |
| 分子式 | C19H22O2 |
| 分子量 | 282.38 |
| EINECS号 | 1806241-263-5 |
| 相关类别 | Various Metabolites and Impurities;Metabolites & Impurities;Steroids |
| Mol文件 | 633-35-2.mol |
| 结构式 |  |
雄甾-1,4,6-三烯-3,17-二酮 性质
| 熔点 | 164-1650C |
|---|---|
| 沸点 | 452.8±45.0 °C(Predicted) |
| 密度 | 1.16±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 溶于甲醇，溶解度5mg/mL |
| 形态 | 粉末 |
Androsta-1,4,6-triene-3,17-dione 是亲脂性、特异性的芳香酶 (aromatase) 抑制剂，Ki 值为 0.18 μM。Androsta-1,4,6-triene-3,17-dione 可抑制雌激素生物合成，具有避孕作用。Androsta-1,4,6-triene-3,17-dione 能诱导空间记忆障碍。
Ki: 0.18 μM (aromatase)
Androsta-1,4,6-triene-3,17-dione (25-100 mg/kg; s.c.) prevents the normal rise in ovarian estradiol concentrations.
Androsta-1,4,6-triene-3,17-dione may act in vivo to inhibit fertility by inhibition of estrogen biosynthesis .
| Animal Model: | Rats (220-250 g) |
| Dosage: | 25 mg/kg, 100 mg/kg |
| Administration: | Subcutaneous injection |
| Result: | Prevented the normal rise in ovarian estradiol concentrations with a single injection 3 hours before the time of the estrogen surge on proestrus. |
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS号 | BV8082250 |