- 6-Shogaol
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- $0.00 / 25kg
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2024-03-28
- CAS:555-66-8
- Min. Order: 25kg
- Purity: 1%（Water Soluble） 5%
- Supply Ability: Inquiry
- 6-Shogaol
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- $0.00 / 1KG
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2023-09-06
- CAS:555-66-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 6-Shogaol Basic information |
| | 6-Shogaol Chemical Properties |
| Boiling point | 427.5±35.0 °C(Predicted) | | density | 1.0448 g/cm3(Temp: 25 °C) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | | pka | 10.01±0.20(Predicted) | | color | Colourless to Light Yellow | | BRN | 2056098 | | InChI | InChI=1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3 | | InChIKey | OQWKEEOHDMUXEO-BQYQJAHWSA-N | | SMILES | C(C1=CC=C(O)C(OC)=C1)CC(=O)C=CCCCCC | | LogP | 3.789 (est) | | CAS DataBase Reference | 555-66-8(CAS DataBase Reference) | | NIST Chemistry Reference | 6-shogaol(555-66-8) |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | 6-Shogaol Usage And Synthesis |
| Uses | [6]-Shogaol is an aromatic constituent of ginger and the chain-dehydroxylated analog of [6]-Gingerol. [6]-Shogaol has activity very similar to [6]-Gingerol and produced an inhibition of spontaneous motor activity, antipyretic and analgesic effects, and prolonged hexobarbital-induced sleeping time. [6]-Shogaol also has potent antitussive activity and affected the cortical EEG. | | Definition | ChEBI: [6]-Shogaol is a monomethoxybenzene, a member of phenols and an enone. | | Anticancer Research | 6-Shogaol is the dehydrated product of 6-gingerol, extracted from the rhizome ofginger. Treatment of HCC cell line with 6-shogaol resulted in cells with apoptoticphenotypes, which showed signs of cell and nuclear shrinkage as well as substantialchromatin condensation. De-phosphorylation of PERK and activation of theexpression of CHOP initiate caspase cascade reaction inducing apoptosis inHCC. Two-dimensional gel electrophoretic analysis of proteome revealed that in response to the treatment with 6-shogaol, a significant stimulation was observed inproteins related to the ER stress, signifying that apoptosis induced by 6-shogoal didinvolve ER stress. Cells showed marked rise in the UPR target expression, HSP70,Grp94, Grp78/Bip and the other ER chaperones on exposure to 6-shogoal in a time-dependentmanner, which elicited activation of caspase-3 and degradation of polyADP ribose polymerase (PARP). Various ER chaperone proteins improve adaptationof cancer cells to hypoxic environment and aid in developing resistance againstanticancer therapy (Zorzi and Bonvini 2011; Urra et al. 2016). Screening of specificinhibitors of Grp78 as antitumour agents (Hu et al. 2012; Liu et al. 2013; Venkatesanet al. 2015) implies that inhibition of Grp78/Bip is a very promising anticancerstrategy. HCC cells are selectively killed by 6-shogaol in the absence of anynoticeable toxic consequence on normal healthy cells and very little toxicity asstudied on SMMC7721 xenograft mice. Administration of 6-shogaol and salubrinaltogether for distinct time intervals resulted in significant increase in ER stress in thecell. It appears that 6-shogaol in combination with salubrinal has great therapeuticvalue against various malignancies including HCC (Hu et al. 2012). |
| | 6-Shogaol Preparation Products And Raw materials |
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